Trimetoquinol HCl hydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526508

CAS#: 72534-66-8 (HCl hydrate)

Description: Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

Chemical Structure

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Trimetoquinol HCl hydrate
CAS# 72534-66-8 (HCl hydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 526508
Name: Trimetoquinol HCl hydrate
CAS#: 72534-66-8 (HCl hydrate)
Chemical Formula: C19H26ClNO6
Exact Mass: 399.14
Molecular Weight: 399.868
Elemental Analysis: C, 57.07; H, 6.55; Cl, 8.87; N, 3.50; O, 24.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 72534-66-8 (HCl hydrate)   18559-59-6 (HCl)   30418-38-3 (free base)    

Synonym: RO 07-5965; RO07-5965 RO-07-5965; Trimetoquinol hydrochloride.

IUPAC/Chemical Name: (S)-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride hydrate

InChi Key: NYRVBYLXLHGXDP-UTLKBRERSA-N

InChi Code: InChI=1S/C19H23NO5.ClH.H2O/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;;/h7-10,14,20-22H,4-6H2,1-3H3;1H;1H2/t14-;;/m0../s1

SMILES Code: OC1=CC2=C([C@H](CC3=CC(OC)=C(OC)C(OC)=C3)NCC2)C=C1O.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 399.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Miller DD, Osei-Gyimah P, Raman RV, Feller DR. Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective beta-adrenergic properties. J Med Chem. 1977 Nov;20(11):1502-4. PubMed PMID: 21293.

2: Nishi H, Fukuyama T, Matsuo M, Terabe S. Chiral separation of diltiazem, trimetoquinol and related compounds by micellar electrokinetic chromatography with bile salts. J Chromatogr. 1990 Aug 31;515:233-43. PubMed PMID: 2283364.

3: Himori N, Taira N. Assessment of the selectivity of OPC-2009, a new beta2-adrenoceptor stimulatn, by the use of the blood-perfused trachea in situ and of the isolated blood-perfused papillary muscle of the dog. Br J Pharmacol. 1977 Sep;61(1):9-17. PubMed PMID: 21014; PubMed Central PMCID: PMC1667687.

4: Ikezawa K, Narita H, Ikeo T, Umino N, Iwakuma T, Sato M. [Bronchodilating and cardiovascular actions of (-)-1-(3, 4, 5-trimethoxybenzyl)-5, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride (l-DTI) in the anesthetized dog (author's transl)]. Nihon Yakurigaku Zasshi. 1978 Sep;74(6):663-70. Japanese. PubMed PMID: 711026.

5: Ikezawa K, Nagao T, Sato M, Nakajima H, Kiyomoto A. [Vasodilator action of (+/-)-1-(3, 4, 5-trimethoxybenzyl)-6-hydroxy-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride (CV-705) in anesthetized dogs (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Oct;73(7):735-42. Japanese. PubMed PMID: 598783.

6: Nishi H, Nakamura K, Nakai H, Sato T, Terabe S. Enantiomeric separation of drugs by affinity electrokinetic chromatography using dextran sulfate. Electrophoresis. 1994 Oct;15(10):1335-40. PubMed PMID: 7895729.

7: Brode E, Binder R, Breckwoldt W. [Determination of trimethoquinol in plasma by electrochemical detection after HPLC separation]. Arzneimittelforschung. 1986 Mar;36(3):437-42. German. PubMed PMID: 3707662.

8: Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24. PubMed PMID: 537270.

9: Irie Y, Igawa T, Hosokawa T, Saitoh Y. Alterations in blood levels of carbohydrate and lipid metabolites and of cyclic AMP mediated by beta1- and beta2-adrenoceptors in beagle dogs: effects of procaterol, a new selective beta2-adrenoceptor agonist. Eur J Pharmacol. 1979 Feb 1;53(4):351-8. PubMed PMID: 33812.