Triclofenol piperazine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526503

CAS#: 5714-82-9

Description: Triclofenol piperazine helps with the treatment of patients imfected with parasite such as hookworms.

Chemical Structure

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Triclofenol piperazine
CAS# 5714-82-9
Instruction

Theoretical Analysis

MedKoo Cat#: 526503
Name: Triclofenol piperazine
CAS#: 5714-82-9
Chemical Formula: C10H11Cl3N2O2
Exact Mass: 295.99
Molecular Weight: 297.560
Elemental Analysis: C, 40.36; H, 3.73; Cl, 35.74; N, 9.41; O, 10.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CI-416; CI416; CI 416; Triclofenol piperazine; Triclofenol piperazate; Triclofenol piperazina

IUPAC/Chemical Name: piperazin-2-one compound with 2,4,5-trichlorophenol (1:1)

InChi Key: QGQSHAPJZVFLPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H3Cl3O.C4H8N2O/c7-3-1-5(9)6(10)2-4(3)8;7-4-3-5-1-2-6-4/h1-2,10H;5H,1-3H2,(H,6,7)

SMILES Code: OC1=CC(Cl)=C(Cl)C=C1Cl.O=C2NCCNC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: SHORT FW, ELSLAGER EF. INTESTINAL ANTHELMINTICS. I. THE PREPARATION OF BIS(2,4,5TRICHLOROPHENOL)-PIPERAZINE SALT (TRICLOFENOL PIPERAZINE) AND OTHER PHENOL-PIPERAZINE SALTS. J Med Pharm Chem. 1962 May;91:642-6. PubMed PMID: 14056397.

2: WAGNER ED, ANDERSON MG Jr. TREATMENT OF INTESTINAL HELMINTHS IN NIGERIA WITH TRICLOFENOL PIPERAZINE. Trans R Soc Trop Med Hyg. 1963 Jul;57:293-6. PubMed PMID: 14047027.

3: PENA CHAVARRIA A, LIZANO C, COURTNEY KO, THOMPSON PE. THE EFFECTS OF TRICLOFENOL PIPERAZINE IN PATIENTS PARASITIZED BY HOOKWORMS, ASCARDIDS, OR TRICHURIDS. Am J Trop Med Hyg. 1963 May;12:378-82. PubMed PMID: 14044748.

4: WAKS J. The hookworm problem in the greater Buenos Aires area with particular references to the therapeutic efficacy of triclofenol piperazine. Am J Trop Med Hyg. 1963 Jan;12:56-9. PubMed PMID: 13998398.

5: Hunter GW 3rd, Davidson C. The effectiveness of a single dose of triclofenol piperazine (Ranestol) against light hookworm infections. Mil Med. 1966 Jan;131(1):48-51. PubMed PMID: 4954872.