Oxiconazole nitrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318399

CAS#: 64211-46-7 (nitrate)

Description: Oxiconazole is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.).

Chemical Structure

Oxiconazole nitrate
CAS# 64211-46-7 (nitrate)

Theoretical Analysis

MedKoo Cat#: 318399
Name: Oxiconazole nitrate
CAS#: 64211-46-7 (nitrate)
Chemical Formula: C18H14Cl4N4O4
Exact Mass:
Molecular Weight: 492.1402
Elemental Analysis: C, 43.93; H, 2.87; Cl, 28.82; N, 11.38; O, 13.00

Price and Availability

Size Price Availability Quantity
1.0g USD 350.0 2 Weeks
5.0g USD 650.0 2 Weeks
10.0g USD 950.0 2 Weeks
20.0g USD 1650.0 2 Weeks
50.0g USD 2950.0 2 Weeks
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Related CAS #: 64211-45-6 (free base)   64211-46-7 (nitrate)    

Synonym: Oxiconazole, Oxistat, Oxizole, Fonx, Myfungar; Ro 13-8996; Ro-13-8996; Ro13-8996; Sgd 301-76; ST 813; ST-813; ST813;

IUPAC/Chemical Name: (Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine;nitric acid


InChi Code: InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;

SMILES Code: C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 492.1402 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Özdemir S, Tuncer Ü, Tarkan Ö, Akar F, Sürmelioğlu Ö. Effects of topical oxiconazole and boric acid in alcohol solutions to rat inner ears. Otolaryngol Head Neck Surg. 2013 Jun;148(6):1023-7. doi: 10.1177/0194599813481565. Epub 2013 Mar 12. PubMed PMID: 23482479.

2: Aydın E, Taştan E, Aydoǧan F, Karaca G, Asım Şafak M. Ototoxic effect of topical oxiconazole and terbinafine in rats. J Otolaryngol Head Neck Surg. 2012 Apr;41(2):78-83. PubMed PMID: 22569007.

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4: Milanese L, Giacchè N, Schiaffella F, Vecchiarelli A, Macchiarulo A, Fringuelli R. Oxime and oxime ether derivatives of 1,4-benzothiazine related to oxiconazole. ChemMedChem. 2007 Aug;2(8):1208-13. PubMed PMID: 17541993.

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6: Milano J, Morsch LM, Cardoso SG. LC method for the analysis of Oxiconazole in pharmaceutical formulations. J Pharm Biomed Anal. 2002 Sep 5;30(2):175-80. PubMed PMID: 12191701.

7: Ablon G, Rosen T, Spedale J. Comparative efficacy of naftifine, oxiconazole, and terbinafine in short-term treatment of tinea pedis. Int J Dermatol. 1996 Aug;35(8):591-3. PubMed PMID: 8854165.

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11: Ramelet AA, Walker-Nasir E. One daily application of oxiconazole cream is sufficient for treating dermatomycoses. Dermatologica. 1987;175(6):293-5. PubMed PMID: 3319722.

12: Wagner W. [Comparison of clinical efficacy and tolerance of oxiconazole administered 1 x daily or 2 x daily]. Mykosen. 1986 Jun;29(6):280-4. German. PubMed PMID: 3762589.

13: Polak-Wyss A, Lengsfeld H, Oesterhelt G. Effect of oxiconazole and Ro 14-4767/002 on sterol pattern in Candida albicans. Sabouraudia. 1985 Dec;23(6):433-41. PubMed PMID: 3913013.

14: Stüttgen G, Bauer E. [Permeation of labeled Oxiconazole. Comparison between the autoradiographic and horizontal slice technics with human skin]. Mykosen. 1985 Mar;28(3):138-47. German. PubMed PMID: 3990703.

15: Gip L. Comparison of oxiconazole (Ro 13-8996) and econazole in dermatomycoses. Mykosen. 1984 Jun;27(6):295, 298-302. PubMed PMID: 6382000.

16: Gebhart RJ, Espinel-Ingroff A, Shadomy S. In vitro susceptibility studies with oxiconazole (Ro 13-8996). Chemotherapy. 1984;30(4):244-7. PubMed PMID: 6086246.

17: Timm U, Zell M, Herzfeld L. Sensitive gas-liquid chromatographic method for the determination of oxiconazole in plasma. J Chromatogr. 1982 Apr 16;229(1):111-20. PubMed PMID: 7085818.

18: Polak A. Oxiconazole, a new imidazole derivative. Evaluation of antifungal activity in vitro and in vivo. Arzneimittelforschung. 1982;32(1):17-24. PubMed PMID: 7037014.

19: Bhandari K, Srinivas N, Shiva Keshava GB, Shukla PK. Tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. Eur J Med Chem. 2009 Jan;44(1):437-47. doi: 10.1016/j.ejmech.2008.01.006. Epub 2008 Jan 25. PubMed PMID: 18313805.

20: Pereiro MJ, Iglesias-Grobas A, Pérez JT. [In vitro comparison of antifungal activity of oxiconazole and econazole against yeast.]. Rev Iberoam Micol. 1998 Jun;15(2):75-7. Spanish. PubMed PMID: 17655413.