WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318398

CAS#: 28721-07-5

Description: Oxcarbazepine is an anticonvulsant drug primarily used in the treatment of epilepsy. There is some evidence for oxcarbazepine as a mood-stabilizing agent and thus, it can be used as add-on therapy for bipolar disorder in patients that have failed or are unable to tolerate approved treatments.

Chemical Structure

CAS# 28721-07-5

Theoretical Analysis

MedKoo Cat#: 318398
Name: Oxcarbazepine
CAS#: 28721-07-5
Chemical Formula: C15H12N2O2
Exact Mass: 252.0899
Molecular Weight: 252.268
Elemental Analysis: C, 71.42; H, 4.79; N, 11.10; O, 12.68

Price and Availability

Size Price Availability Quantity
50.0mg USD 200.0 2 Weeks
100.0mg USD 250.0 2 Weeks
200.0mg USD 280.0 2 Weeks
500.0mg USD 300.0 2 Weeks
1.0g USD 350.0 2 Weeks
2.0g USD 400.0 2 Weeks
5.0g USD 450.0 2 Weeks
10.0g USD 550.0 2 Weeks
20.0g USD 650.0 2 Weeks
50.0g USD 850.0 2 Weeks
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Synonym: Oxcarbazepine, GP 47680, Timox, Trileptal

IUPAC/Chemical Name: 5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide


InChi Code: InChI=1S/C15H12N2O2/c16-15(18)12-9-10-5-1-3-7-13(10)17(19)14-8-4-2-6-11(12)14/h1-6,8-9H,7H2,(H2,16,18)

SMILES Code: O=C(C1=CC2=CC=CCC2=[N+]([O-])C3=CC=CC=C13)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 252.268 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang Z, Xu X, Sun L, Zhao X, Wang H, Fawcett JP, Yang Y, Gu J. Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:36-42. doi: 10.1016/j.jchromb.2016.03.013. Epub 2016 Mar 15. Review. PubMed PMID: 27003707.

2: Fang S, Gong ZC. [Adverse effects of oxcarbazepine]. Zhongguo Dang Dai Er Ke Za Zhi. 2015 Apr;17(4):414-9. Review. Chinese. PubMed PMID: 25919567.

3: Kaniwa N, Saito Y. The risk of cutaneous adverse reactions among patients with the HLA-A* 31:01 allele who are given carbamazepine, oxcarbazepine or eslicarbazepine: a perspective review. Ther Adv Drug Saf. 2013 Dec;4(6):246-53. doi: 10.1177/2042098613499791. Review. PubMed PMID: 25114785; PubMed Central PMCID: PMC4125310.

4: Zaccara G, Giovannelli F, Maratea D, Fadda V, Verrotti A. Neurological adverse events of new generation sodium blocker antiepileptic drugs. Meta-analysis of randomized, double-blinded studies with eslicarbazepine acetate, lacosamide and oxcarbazepine. Seizure. 2013 Sep;22(7):528-36. doi: 10.1016/j.seizure.2013.03.016. Epub 2013 Apr 25. Review. PubMed PMID: 23623245.

5: Fanella M, Egeo G, Fattouch J, Casciato S, Lapenta L, Morano A, Giallonardo AT, Di Bonaventura C. Oxcarbazepine-induced myoclonic status epilepticus in juvenile myoclonic epilepsy. Epileptic Disord. 2013 Jun;15(2):181-7. doi: 10.1684/epd.2013.0563. Review. PubMed PMID: 23774821.

6: Nolan SJ, Muller M, Tudur Smith C, Marson AG. Oxcarbazepine versus phenytoin monotherapy for epilepsy. Cochrane Database Syst Rev. 2013 May 31;(5):CD003615. doi: 10.1002/14651858.CD003615.pub3. Review. PubMed PMID: 23728645.

7: Zhou M, Chen N, He L, Yang M, Zhu C, Wu F. Oxcarbazepine for neuropathic pain. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007963. doi: 10.1002/14651858.CD007963.pub2. Review. PubMed PMID: 23543558.

8: Cárdenas-Rodríguez N, Coballase-Urrutia E, Rivera-Espinosa L, Romero-Toledo A, Sampieri A 3rd, Ortega-Cuellar D, Montesinos-Correa H, Floriano-Sánchez E, Carmona-Aparicio L. Modulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental models. Oxid Med Cell Longev. 2013;2013:598493. doi: 10.1155/2013/598493. Epub 2013 Dec 17. Review. PubMed PMID: 24454986; PubMed Central PMCID: PMC3877618.

9: Vasudev A, Macritchie K, Vasudev K, Watson S, Geddes J, Young AH. Oxcarbazepine for acute affective episodes in bipolar disorder. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD004857. doi: 10.1002/14651858.CD004857.pub2. Review. PubMed PMID: 22161387.

10: Barrons R, Roberts N. The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome. J Clin Pharm Ther. 2010 Apr;35(2):153-67. doi: 10.1111/j.1365-2710.2009.01098.x. Review. PubMed PMID: 20456734.

11: Bouquié R, Dailly E, Bentué-Ferrer D; le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique. [Therapeutic drug monitoring of oxcarbazepine]. Therapie. 2010 Jan-Feb;65(1):61-5. doi: 10.2515/therapie/2009070. Epub 2010 Mar 8. Review. French. PubMed PMID: 20205998.

12: Koch MW, Polman SK. Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD006453. doi: 10.1002/14651858.CD006453.pub2. Review. PubMed PMID: 19821367.

13: Bring P, Ensom MH. Does oxcarbazepine warrant therapeutic drug monitoring? A critical review. Clin Pharmacokinet. 2008;47(12):767-78. doi: 10.2165/0003088-200847120-00002. Review. PubMed PMID: 19026033.

14: Nasreddine W, Beydoun A. Oxcarbazepine in neuropathic pain. Expert Opin Investig Drugs. 2007 Oct;16(10):1615-25. Review. PubMed PMID: 17922625.

15: Knudsen JF, Flowers CM, Kortepeter C, Awaad Y. Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review. Pediatr Neurol. 2007 Aug;37(2):134-7. Review. PubMed PMID: 17675030.

16: Popova E, Leighton C, Bernabarre A, Bernardo M, Vieta E. Oxcarbazepine in the treatment of bipolar and schizoaffective disorders. Expert Rev Neurother. 2007 Jun;7(6):617-26. Review. PubMed PMID: 17563245.

17: Muller M, Marson AG, Williamson PR. Oxcarbazepine versus phenytoin monotherapy for epilepsy. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD003615. Review. Update in: Cochrane Database Syst Rev. 2013;5:CD003615. PubMed PMID: 16625587.

18: Horga de la Parte JF, Horga A. [Oxcarbazepine in the treatment of epilepsy. A review and update]. Rev Neurol. 2006 Jan 16-31;42(2):95-113. Review. Spanish. PubMed PMID: 16450324.

19: Hirschfeld RM, Kasper S. A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder. Int J Neuropsychopharmacol. 2004 Dec;7(4):507-22. Epub 2004 Sep 30. Review. PubMed PMID: 15458610.

20: Centorrino F, Albert MJ, Berry JM, Kelleher JP, Fellman V, Line G, Koukopoulos AE, Kidwell JE, Fogarty KV, Baldessarini RJ. Oxcarbazepine: clinical experience with hospitalized psychiatric patients. Bipolar Disord. 2003 Oct;5(5):370-4. Review. PubMed PMID: 14525559.