ACC-789
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MedKoo CAT#: 406754

CAS#: 300842-64-2

Description: ACC-789, also known as NVP-ACC789 and ZK-202650, is a potent, selective and orally active inhibitor of the VEGF receptor tyrosine kinases with potential anticancer activity.


Chemical Structure

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ACC-789
CAS# 300842-64-2

Theoretical Analysis

MedKoo Cat#: 406754
Name: ACC-789
CAS#: 300842-64-2
Chemical Formula: C21H17BrN4
Exact Mass: 404.0637
Molecular Weight: 405.299
Elemental Analysis: C, 62.23; H, 4.23; Br, 19.71; N, 13.82

Price and Availability

Size Price Availability Quantity
50.0mg USD 190.0 Same Day
100.0mg USD 350.0 Same Day
200.0mg USD 650.0 Same Day
500.0mg USD 1350.0 Same Day
1.0g USD 2250.0 Same Day
2.0g USD 3650.0 Same Day
5.0g USD 5650.0 2 Weeks
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Synonym: NVP-ACC789; NVP-ACC 789; NVP-ACC-789; ACC-789; ACC 789; ACC789; ZK-202650; ZK 202650; ZK202650.

IUPAC/Chemical Name: N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

InChi Key: GXWKSXUPEFVUOO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)

SMILES Code: CC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Biological target: NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.0 32.08
DMF 0.5 1.23
DMF:PBS (pH 7) (1:10) 0.09 0.22
Ethanol 0.2 0.49

Preparing Stock Solutions

The following data is based on the product molecular weight 405.299 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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ACC-789

50.0mg / USD 190.0