Nitrazepam

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MedKoo CAT#: 318370

CAS#: 146-22-5

Description: Nitrazepam is a hypnotic drug of the benzodiazepine class. It is indicated for the short-term relief of severe, disabling anxiety and insomnia. Nitrazepam also has sedative and motor-impairing properties, as well as amnestic, anticonvulsant, and skeletal muscle relaxant effects. Nitrazepam is discontinued (DEA controlled substance).


Price and Availability

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Pricing updated 2020-11-23. Prices are subject to change without notice.

Nitrazepam is discontinued (DEA controlled substance).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318370
Name: Nitrazepam
CAS#: 146-22-5
Chemical Formula: C15H11N3O3
Exact Mass: 281.08
Molecular Weight: 281.2661
Elemental Analysis: C, 64.05; H, 3.94; N, 14.94; O, 17.07


Synonym: Nitrazepam, Benzalin, Mogadon, Remnos, Nitrados, Imeson

IUPAC/Chemical Name: 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

InChi Key: KJONHKAYOJNZEC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)

SMILES Code: O=C1NC2=CC=C([N+]([O-])=O)C=C2C(C3=CC=CC=C3)=NC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kangas L, Breimer DD. Clinical pharmacokinetics of nitrazepam. Clin Pharmacokinet. 1981 Sep-Oct;6(5):346-66. Review. PubMed PMID: 7037262.

2: Yasuda K. [Benzodiazepine (clonazepam, nitrazepam, diazepam)]. Nihon Rinsho. 2004 Dec;62 Suppl 12:360-3. Review. Japanese. PubMed PMID: 15658338.

3: Yasuda K. [Benzodiazepine (clonazepam, nitrazepam, diazepam)]. Nihon Rinsho. 1999 Sep;57 Suppl:364-7. Review. Japanese. PubMed PMID: 10543128.

4: Brødsgaard I, Hansen AC, Vesterby A. Two cases of lethal nitrazepam poisoning. Am J Forensic Med Pathol. 1995 Jun;16(2):151-3. Review. PubMed PMID: 7572872.

5: Yasuda K. [Clonazepam, nitrazepam, diazepam]. Nihon Rinsho. 1995 Feb;53 Su Pt 1:911-4. Review. Japanese. PubMed PMID: 8753585.

6: Lim HC, Nigro MA, Beierwaltes P, Tolia V, Wishnow R. Nitrazepam-induced cricopharyngeal dysphagia, abnormal esophageal peristalsis and associated bronchospasm: probable cause of nitrazepam-related sudden death. Brain Dev. 1992 Sep;14(5):309-14. Review. PubMed PMID: 1456385.