Tamolarizine free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326659

CAS#: 128229-52-7

Description: Tamolarizine, also known as NC-1100, a novel calcium antagonist. NC-1100 may show a behavior-facilitating effect, although its effect is mild and different from that of typical central stimulants such as methamphetamine. NC-1100 may be a drug inducing the increase of GABA in the cerebellum and medulla oblongata following continuous administration, especially in animals having hypertension associated cerebrovascular disorders such as SHR-SP.

Chemical Structure

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Tamolarizine free base
CAS# 128229-52-7
Instruction

Theoretical Analysis

MedKoo Cat#: 326659
Name: Tamolarizine free base
CAS#: 128229-52-7
Chemical Formula: C27H32N2O3
Exact Mass: 432.24
Molecular Weight: 432.564
Elemental Analysis: C, 74.97; H, 7.46; N, 6.48; O, 11.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NC-1100; NC 1100; NC1100; Tamolarizine; Tamolarizine HCl; Tamolarizine dihyrchloride.

IUPAC/Chemical Name: 2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethan-1-ol

InChi Key: PIKMDZDCXCAPEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H32N2O3/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-14,19,24,27,30H,15-18,20H2,1-2H3

SMILES Code: OC(C1=CC=C(OC)C(OC)=C1)CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 432.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Miyake N, Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K. Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8. PubMed PMID: 10887958.

2: Tamura R, Nakada Y, Nishijo H, Miyake N, Ono T. Ameliorative effects of tamolarizine on place learning impairment induced by transient forebrain ischemia in rats. Brain Res. 2000 Jan 17;853(1):81-92. PubMed PMID: 10627311.

3: Nomura Y, Yamakawa T, Nishioka K, Omura T, Miyake N, Masaki M, Nohira H. Synthesis and structure-activity relationships of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols as new calcium blockers. Chem Pharm Bull (Tokyo). 1995 Feb;43(2):241-6. PubMed PMID: 7537178.

4: Nishijo H, Tabuchi E, Ono T, Fukuda M, Kuze S, Endo S. Physiological results of monkey brain ischemia, and protection by a calcium blocker. Brain Res Bull. 1995;37(1):89-101. PubMed PMID: 7606483.

5: Matsumura T, Furuichi H, Izumi J, Kamatsuka Y, Takei M, Nakata N, Ito S, Suda H, Kizaki K, Kurimoto T. [Effects of NC-1100, a calcium channel blocker, on experimental cerebral ischemia/anoxia in rodents]. Nihon Yakurigaku Zasshi. 1993 Mar;101(3):177-86. Japanese. PubMed PMID: 8486322.

6: Miyake N, Wakamori M, Akaike N. A new type of Ca2+ channel blocker, NC-1100, inhibits the low- and high-threshold Ca2+ currents in the rat CNS neurons. Brain Res. 1992 Dec 11;598(1-2):215-20. PubMed PMID: 1486482.

7: Sadoshima S, Ibayashi S, Nakane H, Okada Y, Ooboshi H, Fujishima M. Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats. Eur J Pharmacol. 1992 Dec 2;224(2-3):109-15. PubMed PMID: 1468503.

8: Nishijo H, Kuze S, Ono T, Tabuchi E, Endo S, Kogure K. Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus. Brain Res Bull. 1992 Sep-Oct;29(3-4):519-24. PubMed PMID: 1393625.

9: Tanabe K, Kinoshita Y, Tokuyoshi K, Houri D, Kimishima K. [Effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol dihydrochloride (NC-1100) on the central nervous system]. Nihon Yakurigaku Zasshi. 1991 Nov;98(5):357-68. Japanese. PubMed PMID: 1813367.

10: Miyake N, Takayanagi I. Stereoselectivity of NC-1100, a Ca-entry blocker. Gen Pharmacol. 1990;21(2):261-3. PubMed PMID: 2332145.

11: Hashimoto T, Kimori M, Nakamura Y, Kuriyama K. Effect of NC-1100 [1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride] on gamma-aminobutyric acid (GABA) metabolism in rat brain: analysis using stroke-prone spontaneously hypertensive rat. Jpn J Pharmacol. 1989 Jun;50(2):131-9. PubMed PMID: 2770051.

12: Kushiku K, Ohba M, Araki T, Mikagi T, Katsuragi T, Furukawa T. Cardiovascular effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol and possible mechanisms involved. Arzneimittelforschung. 1989 Apr;39(4):458-63. PubMed PMID: 2751731.

13: Kuribara H, Tadokoro S. [Behavioral effects of NC-1100, 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride--on ambulatory activity, discrete lever-press response and shuttle avoidance response in mice]. Nihon Yakurigaku Zasshi. 1989 Apr;93(4):245-53. Japanese. PubMed PMID: 2744654.

14: Izumiyama K, Kogure K. Prevention of delayed neuronal death in gerbil hippocampus by ion channel blockers. Stroke. 1988 Aug;19(8):1003-7. PubMed PMID: 2456632.

15: Takayanagi I, Koike K, Miyake N, Sato R, Yamada K. Selectivity of cerebral vasodilators on basilar arteries. Gen Pharmacol. 1986;17(4):505-7. PubMed PMID: 3758658.