MN-64
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MedKoo CAT#: 406732

CAS#: 92831-11-3

Description: MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2150 2 Weeks
1g USD 2950 2 Weeks
2g USD 4250 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

MN-64, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406732
Name: MN-64
CAS#: 92831-11-3
Chemical Formula: C18H16O2
Exact Mass: 264.115
Molecular Weight: 264.324
Elemental Analysis: C, 81.79; H, 6.10; O, 12.11


Synonym: MN-64; MN 64; MN64.

IUPAC/Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

InChi Key: PYTOHIUBXSJKQH-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3

SMILES Code: O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H,
Joensuu P, Pihlajaniemi T, Lehtiö L. Discovery of tankyrase inhibiting flavones
with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct
24;56(20):7880-9. doi: 10.1021/jm401463y. Epub 2013 Oct 11. PubMed PMID:
24116873.