BMS-3
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MedKoo CAT#: 526649

CAS#: 1338247-30-5

Description: BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.

Chemical Structure

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BMS-3
CAS# 1338247-30-5
Instruction

Theoretical Analysis

MedKoo Cat#: 526649
Name: BMS-3
CAS#: 1338247-30-5
Chemical Formula: C17H12Cl2F2N4OS
Exact Mass: 428.01
Molecular Weight: 429.267
Elemental Analysis: C, 47.57; H, 2.82; Cl, 16.52; F, 8.85; N, 13.05; O, 3.73; S, 7.47

Price and Availability

Size Price Availability Quantity
10mg USD 150 2 weeks
25mg USD 250 2 weeks
50mg USD 450 2 weeks
100mg USD 850 2 weeks
200mg USD 1250 2 weeks
500mg USD 1950 2 weeks
1g USD 2850 2 weeks
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Synonym: BMS-3; BMS 3; BMS3.

IUPAC/Chemical Name: N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide

InChi Key: YBGGBHCJSAEIAS-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)

SMILES Code: O=C(C1CC1)NC2=NC=C(C3=CC(C(F)F)=NN3C4=C(Cl)C=CC=C4Cl)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li X, Zhu Y, Cao Y, Wang Q, Du J, Tian J, Liang Y, Ma W. LIM kinase activity
is required for microtubule organising centre positioning in mouse oocyte
meiosis. Reprod Fertil Dev. 2016 Jan 6. doi: 10.1071/RD15406. [Epub ahead of
print] PubMed PMID: 26733281.