WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406726
CAS#: 1962928-21-7 (free base)
Description: PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.
MedKoo Cat#: 406726
Name: PF-CBP1 free base
CAS#: 1962928-21-7 (free base)
Chemical Formula: C29H36N4O3
Exact Mass: 488.2787
Molecular Weight: 488.632
Elemental Analysis: C, 71.28; H, 7.43; N, 11.47; O, 9.82
Related CAS #: 1962928-21-7 (free base) 2070014-93-4 (HCl)
Synonym: PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910.
IUPAC/Chemical Name: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine
InChi Key: CGWBJJZOKGZCSJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3
SMILES Code: CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1
1: Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J,
Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH.
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain
Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec
17;22(12):1588-96. doi: 10.1016/j.chembiol.2015.10.013. Epub 2015 Dec 3. PubMed
PMID: 26670081.