PF-CBP1 free base
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MedKoo CAT#: 406726

CAS#: 1962928-21-7 (free base)

Description: PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.

Chemical Structure

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PF-CBP1 free base
CAS# 1962928-21-7 (free base)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 406726
Name: PF-CBP1 free base
CAS#: 1962928-21-7 (free base)
Chemical Formula: C29H36N4O3
Exact Mass: 488.28
Molecular Weight: 488.632
Elemental Analysis: C, 71.28; H, 7.43; N, 11.47; O, 9.82

Price and Availability

Size Price Availability Quantity
10mg USD 90
25mg USD 150
50mg USD 250
100mg USD 450
200mg USD 750
500mg USD 1550
1g USD 2850
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Related CAS #: 1962928-21-7 (free base)   2070014-93-4 (HCl)    

Synonym: PF-CBP1; PF-CBP-1; PF-CBP 1; PF-06670910; PF 06670910; PF06670910.

IUPAC/Chemical Name: 4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine

InChi Key: CGWBJJZOKGZCSJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H36N4O3/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32/h5-6,8-11,20H,4,7,12-19H2,1-3H3

SMILES Code: CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 61.40
DMF:PBS (pH 7.2) (1:1) 0.5 1.02
DMSO 20.0 40.93
Ethanol 20.0 40.93

Preparing Stock Solutions

The following data is based on the product molecular weight 488.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J,
Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH.
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain
Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec
17;22(12):1588-96. doi: 10.1016/j.chembiol.2015.10.013. Epub 2015 Dec 3. PubMed
PMID: 26670081.