BMS-247243

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524458

CAS#: 307316-55-8

Description: BMS-247243 is a novel cephalosporin inhibitory for methicillin-resistant staphylococci. It primarily has activity against gram-positive bacteria. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

Chemical Structure

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BMS-247243
CAS# 307316-55-8
Instruction

Theoretical Analysis

MedKoo Cat#: 524458
Name: BMS-247243
CAS#: 307316-55-8
Chemical Formula: C36H41Cl2N5O8S3
Exact Mass: 837.15
Molecular Weight: 838.840
Elemental Analysis: C, 51.55; H, 4.93; Cl, 8.45; N, 8.35; O, 15.26; S, 11.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BMS-247243; BMS 247243; BMS247243; UNII-KG8365V22L.

IUPAC/Chemical Name: (6R,7R)-7-(2-((4-((E)-3-((carboxylatomethyl)amino)-3-oxoprop-1-en-1-yl)-2,5-dichlorophenyl)thio)acetamido)-3-(((2,6-dimethyl-1-(3-(4-methylmorpholino-4-ium)propyl)pyridin-1-ium-4-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

InChi Key: MOYDKLWHWUTKTI-LDCQLTLFSA-N

InChi Code: InChI=1S/C36H41Cl2N5O8S3/c1-21-13-25(14-22(2)41(21)7-4-8-43(3)9-11-51-12-10-43)52-18-24-19-54-35-32(34(48)42(35)33(24)36(49)50)40-30(45)20-53-28-16-26(37)23(15-27(28)38)5-6-29(44)39-17-31(46)47/h5-6,13-16,32,35H,4,7-12,17-20H2,1-3H3,(H2-2,39,40,44,45,46,47,49,50)/b6-5+/t32-,35-/m1/s1

SMILES Code: Cc1cc(cc([n+]1CCC[N+]2(CCOCC2)C)C)SCC3=C(N4[C@@H]([C@@H](C4=O)NC(=O)CSc5cc(c(cc5Cl)/C=C/C(=O)NCC(=O)[O-])Cl)SC3)C(=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 838.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shahid M, Sobia F, Singh A, Malik A, Khan HM, Jonas D, Hawkey PM. Beta-lactams and beta-lactamase-inhibitors in current- or potential-clinical practice: a comprehensive update. Crit Rev Microbiol. 2009;35(2):81-108. doi: 10.1080/10408410902733979. Review. PubMed PMID: 19514910.

2: Clark J, Fung-Tomc JC, Minassian B, Tsai YH, Yang H, Huczko E, Kolek B, Chaniewski S, Ferraro C, Drain R, Gradelski E, Bonner DP. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci. Antimicrob Agents Chemother. 2002 Apr;46(4):1108-11. PubMed PMID: 11897599; PubMed Central PMCID: PMC127083.

3: Fung-Tomc JC, Clark J, Minassian B, Pucci M, Tsai YH, Gradelski E, Lamb L, Medina I, Huczko E, Kolek B, Chaniewski S, Ferraro C, Washo T, Bonner DP. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci. Antimicrob Agents Chemother. 2002 Apr;46(4):971-6. PubMed PMID: 11897577; PubMed Central PMCID: PMC127082.

4: Johnson AP. Anti-MRSA cephalosporins Bristol-Myers Squibb. Curr Opin Investig Drugs. 2001 Feb;2(2):205-8. Review. PubMed PMID: 11816831.