WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406722
CAS#: 537672-41-6
Description: UF-010 is a Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological activities in suppressing tumor cell proliferation support further preclinical development of the UF010 class of compounds for potential therapeutic applications.
MedKoo Cat#: 406722
Name: UF-010
CAS#: 537672-41-6
Chemical Formula: C11H15BrN2O
Exact Mass: 270.0368
Molecular Weight: 271.158
Elemental Analysis: C, 48.72; H, 5.58; Br, 29.47; N, 10.33; O, 5.90
Synonym: UF-010, UF 010, UF010
IUPAC/Chemical Name: 4-Bromo-N'-butylbenzohydrazide
InChi Key: BVQCFCYPFJOOAV-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
SMILES Code: O=C(NNCCCC)C1=CC=C(Br)C=C1
1: Mahmud I, Liao D. Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors. Genom Data. 2015 Sep 1;5:257-259. PubMed PMID: 26217556; PubMed Central PMCID: PMC4513360.
2: Wang Y, Stowe RL, Pinello CE, Tian G, Madoux F, Li D, Zhao LY, Li JL, Wang Y, Wang Y, Ma H, Hodder P, Roush WR, Liao D. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015 Feb 19;22(2):273-84. doi:
10.1016/j.chembiol.2014.12.015. PubMed PMID: 25699604; PubMed Central PMCID: PMC4365786.
