WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406722

CAS#: 537672-41-6

Description: UF-010 is a Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological activities in suppressing tumor cell proliferation support further preclinical development of the UF010 class of compounds for potential therapeutic applications.

Chemical Structure

CAS# 537672-41-6

Theoretical Analysis

MedKoo Cat#: 406722
Name: UF-010
CAS#: 537672-41-6
Chemical Formula: C11H15BrN2O
Exact Mass: 270.04
Molecular Weight: 271.158
Elemental Analysis: C, 48.72; H, 5.58; Br, 29.47; N, 10.33; O, 5.90

Price and Availability

Size Price Availability Quantity
100mg USD 750
200mg USD 1250
500mg USD 2250
1g USD 3150
2g USD 4950
5g USD 6850
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Synonym: UF-010, UF 010, UF010

IUPAC/Chemical Name: 4-Bromo-N'-butylbenzohydrazide


InChi Code: InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)


Appearance: Crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 271.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mahmud I, Liao D. Microarray gene expression profiling reveals potential mechanisms of tumor suppression by the class I HDAC-selective benzoylhydrazide inhibitors. Genom Data. 2015 Sep 1;5:257-259. PubMed PMID: 26217556; PubMed Central PMCID: PMC4513360.

2: Wang Y, Stowe RL, Pinello CE, Tian G, Madoux F, Li D, Zhao LY, Li JL, Wang Y, Wang Y, Ma H, Hodder P, Roush WR, Liao D. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015 Feb 19;22(2):273-84. doi:
10.1016/j.chembiol.2014.12.015. PubMed PMID: 25699604; PubMed Central PMCID: PMC4365786.