OAC2
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526643

CAS#: 6019-39-2

Description: OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.

Chemical Structure

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OAC2
CAS# 6019-39-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 526643
Name: OAC2
CAS#: 6019-39-2
Chemical Formula: C15H12N2O
Exact Mass: 236.10
Molecular Weight: 236.270
Elemental Analysis: C, 76.25; H, 5.12; N, 11.86; O, 6.77

Price and Availability

Size Price Availability Quantity
100mg USD 250 Same Day
200mg USD 450 Same Day
500mg USD 850 Same Day
1g USD 1450 Same Day
2g USD 2450 Same Day
5g USD 4650
50mg USD 150 Same Day
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Synonym: OAC2; OAC-2; OAC 2.

IUPAC/Chemical Name: N-1H-indol-5-yl-benzamide

InChi Key: JCAFGYWSIWYMOX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12N2O/c18-15(11-4-2-1-3-5-11)17-13-6-7-14-12(10-13)8-9-16-14/h1-10,16H,(H,17,18)

SMILES Code: O=C(NC1=CC2=C(NC=C2)C=C1)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
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Biological target: OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.
In vitro activity: To localize ORS571-oac2 upon coinoculation and to evaluate its nitrogen-fixing potential, plasmids pXLGD4 (carrying a constitutively expressed lacZ gene) (21) and pRS2002 (carrying a nifH-lacZ fusion) (22) were introduced into ORS571-oac2 by triparental mating with pRK2073 (23) as helper plasmid. Mature wild-type nodules on S. rostrata typically retain a globular shape (Fig. 6 A and B, which is published as supporting information on the PNAS web site), whereas ORS571-oac2-induced nodules continued to develop primordia, resulting in large multilobed structures (Fig. 1A). ORS571-oac2-induced nodules at 60 dpi had multiple blue spots on the surface (Fig. 1 A) that corresponded with colonization of the outermost cortical cells and a limited deeper tissue invasion (Fig. 1B). Upon nodule induction with a GUS-marked ORS571-oac2 (Fig. 2D), plant cells of the infection zone had cyan blue precipitates in the cytoplasm (Fig. 2E). TEM confirmed the presence of bacteria in plant cells that, atypically, still contained several vacuoles (Fig. 2F). Based on these observations, we hypothesize that, in the ORS571-oac2–S. rostrata interaction, the absence of a bacterial signal fails to trigger progression of the symbiotic program of the host. Reference: Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7): 2655–2660. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549025/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.0 42.30

Preparing Stock Solutions

The following data is based on the product molecular weight 236.270000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Mathis R, Van Gijsegem F, De Rycke R, D'Haeze W, Van Maelsaeke E, Anthonio E, Van Montagu M, Holsters M, Vereecke D. Lipopolysaccharides as a communication signal for progression of legume endosymbiosis. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2655-60. doi: 10.1073/pnas.0409816102. Epub 2005 Feb 7. PMID: 15699329; PMCID: PMC549025. 2. Wakao S, Siarot L, Aono T, Oyaizu H. Effects of alteration in LPS structure in Azorhizobium caulinodans on nodule development. J Gen Appl Microbiol. 2015;61(6):248-54. doi: 10.2323/jgam.61.248. PMID: 26782655.
In vitro protocol: 1. Mathis R, Van Gijsegem F, De Rycke R, D'Haeze W, Van Maelsaeke E, Anthonio E, Van Montagu M, Holsters M, Vereecke D. Lipopolysaccharides as a communication signal for progression of legume endosymbiosis. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2655-60. doi: 10.1073/pnas.0409816102. Epub 2005 Feb 7. PMID: 15699329; PMCID: PMC549025. 2. Wakao S, Siarot L, Aono T, Oyaizu H. Effects of alteration in LPS structure in Azorhizobium caulinodans on nodule development. J Gen Appl Microbiol. 2015;61(6):248-54. doi: 10.2323/jgam.61.248. PMID: 26782655.
In vivo protocol: TBD

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