AG-18 (Tyrphostin 23)
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MedKoo CAT#: 407346

CAS#: 118409-57-7

Description: AG-18, also known as RG-50810; RG-50858; TX 825; Tyrphostin A23; Tyrphostin AG-18. AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431. AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2850 2 Weeks
2g USD 3950 2 Weeks
5g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

AG-18, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407346
Name: AG-18 (Tyrphostin 23)
CAS#: 118409-57-7
Chemical Formula: C10H6N2O2
Exact Mass: 186.0429
Molecular Weight: 186.17
Elemental Analysis: C, 64.52; H, 3.25; N, 15.05; O, 17.19


Synonym: AG-18; AG 18; AG18; RG-50810; RG-50858; TX 825; Tyrphostin 23; Tyrphostin A23; Tyrphostin AG-18.

IUPAC/Chemical Name: 2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile

InChi Key: VTJXFTPMFYAJJU-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

SMILES Code: N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1


Technical Data

Appearance:
Light yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ortiz-Zapater E, Soriano-Ortega E, Marcote MJ, Ortiz-Masiá D, Aniento F.
Trafficking of the human transferrin receptor in plant cells: effects of
tyrphostin A23 and brefeldin A. Plant J. 2006 Dec;48(5):757-70. Epub 2006 Oct 19.
PubMed PMID: 17059402.

2: Banbury DN, Oakley JD, Sessions RB, Banting G. Tyrphostin A23 inhibits
internalization of the transferrin receptor by perturbing the interaction between
tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. J Biol
Chem. 2003 Apr 4;278(14):12022-8. Epub 2003 Jan 28. PubMed PMID: 12556528.

3: Ogura T, Imanishi S, Shibamoto T. Activation of background membrane
conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive
analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001
Nov;87(3):235-9. PubMed PMID: 11885974.