BI-671800
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524414

CAS#: 1093108-50-9

Description: BI-671800 is a CRTH2 antagonist that treats patients with asthma. BI 671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 650 2 weeks
25mg USD 1240 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

BI-671800, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524414
Name: BI-671800
CAS#: 1093108-50-9
Chemical Formula: C25H26F3N5O3
Exact Mass: 501.19877
Molecular Weight: 501.5
Elemental Analysis: C, 59.87; H, 5.23; F, 11.36; N, 13.96; O, 9.57


Synonym: BI-671800; BI 671800; BI671800.

IUPAC/Chemical Name: 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-((4-((4-(trifluoromethyl)benzoyl)amino)phenyl)methyl)-

InChi Key: XEOSTBFUCNZKGS-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H26F3N5O3/c1-32(2)22-19(14-21(34)35)23(33(3)4)31-20(30-22)13-15-5-11-18(12-6-15)29-24(36)16-7-9-17(10-8-16)25(26,27)28/h5-12H,13-14H2,1-4H3,(H,29,36)(H,34,35)

SMILES Code: CN(C)c1c(c(nc(n1)Cc2ccc(cc2)NC(=O)c3ccc(cc3)C(F)(F)F)N(C)C)CC(=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hall IP, Fowler AV, Gupta A, Tetzlaff K, Nivens MC, Sarno M, Finnigan HA, Bateman ED, Rand Sutherland E. Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment. Pulm Pharmacol Ther. 2015 Jun;32:37-44. doi: 10.1016/j.pupt.2015.03.003. Epub 2015 Apr 8. PubMed PMID: 25861737.

2: Krug N, Gupta A, Badorrek P, Koenen R, Mueller M, Pivovarova A, Hilbert J, Wetzel K, Hohlfeld JM, Wood C. Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 2014 Feb;133(2):414-9. doi: 10.1016/j.jaci.2013.10.013. Epub 2013 Dec 9. PubMed PMID: 24332218.