BAY-60-5521

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524386

CAS#: 893409-49-9

Description: BAY-60-5521 is a potent inhibitor of cholesteryl ester transfer protein (CETP).


Price and Availability

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BAY-60-5521, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524386
Name: BAY-60-5521
CAS#: 893409-49-9
Chemical Formula: C30H37F4NO
Exact Mass: 503.28113
Molecular Weight: 503.61
Elemental Analysis: C, 71.55; H, 7.41; F, 15.09; N, 2.78; O, 3.18


Synonym: BAY-60-5521; BAY605521; BAY 60-5521; UNII-I0J230BJOO;

IUPAC/Chemical Name: (S)-4-cyclohexyl-2-cyclopentyl-3-((S)-fluoro(4-(trifluoromethyl)phenyl)methyl)-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

InChi Key: BHKIPHICFOJGLD-HOFKKMOUSA-N

InChi Code: InChI=1S/C30H37F4NO/c1-29(2)16-22-25(23(36)17-29)24(18-8-4-3-5-9-18)26(28(35-22)20-10-6-7-11-20)27(31)19-12-14-21(15-13-19)30(32,33)34/h12-15,18,20,23,27,36H,3-11,16-17H2,1-2H3/t23-,27-/m0/s1

SMILES Code: CC1(Cc2c(c(c(c(n2)C3CCCC3)[C@H](c4ccc(cc4)C(F)(F)F)F)C5CCCCC5)[C@H](C1)O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Boettcher MF, Heinig R, Schmeck C, Kohlsdorfer C, Ludwig M, Schaefer A, Gelfert-Peukert S, Wensing G, Weber O. Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein. Br J Clin Pharmacol. 2012 Feb;73(2):210-8. doi: 10.1111/j.1365-2125.2011.04083.x. PubMed PMID: 21838789; PubMed Central PMCID: PMC3269580.

2: Weber O, Willmann S, Bischoff H, Li V, Vakalopoulos A, Lustig K, Hafner FT, Heinig R, Schmeck C, Buehner K. Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling. Br J Clin Pharmacol. 2012 Feb;73(2):219-31. doi: 10.1111/j.1365-2125.2011.04064.x. PubMed PMID: 21762205; PubMed Central PMCID: PMC3269581.