Napabucasin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206601

CAS#: 83280-65-3

Description: Napabucasin, also known as BBI-608, is an orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, BBI608 appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies.


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 650
2g
USD 2950
Size
Price

50mg
USD 250
500mg
USD 1250
5g
USD 5950
Size
Price

100mg
USD 450
1g
USD 1650

Napabucasin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206601
Name: Napabucasin
CAS#: 83280-65-3
Chemical Formula: C14H8O4
Exact Mass: 240.0423
Molecular Weight: 240.214
Elemental Analysis: C, 70.00; H, 3.36; O, 26.64


Synonym: BBI608; BBI 608; BB-I608; Napabucasin

IUPAC/Chemical Name: 2-Acetylnaphtho[2,3-b]furan-4,9-dione

InChi Key: DPHUWDIXHNQOSY-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3

SMILES Code: O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Zhang Y, Jin Z, Zhou H, Ou X, Xu Y, Li H, Liu C, Li B. Suppression of prostate
cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med.
2016 Feb 21. doi: 10.1002/cam4.675. [Epub ahead of print] PubMed PMID: 26899963.

2: Li Y, Rogoff HA, Keates S, Gao Y, Murikipudi S, Mikule K, Leggett D, Li W,
Pardee AB, Li CJ. Suppression of cancer relapse and metastasis by inhibiting
cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. doi:
10.1073/pnas.1424171112. Epub 2015 Jan 20. PubMed PMID: 25605917; PubMed Central
PMCID: PMC4330785.