DDR1-IN-1
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MedKoo CAT#: 407343

CAS#: 1449685-96-4

Description: DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 120 Same day
25mg USD 190 Same day
50mg USD 350 Same day
100mg USD 550 Same day
200mg USD 950 Same day
500mg USD 1550 Same day
1g USD 2650 2 Weeks
2g USD 3950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

DDR1-IN-1, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407343
Name: DDR1-IN-1
CAS#: 1449685-96-4
Chemical Formula: C30H31F3N4O3
Exact Mass: 552.2348
Molecular Weight: 552.5982
Elemental Analysis: C, 65.21; H, 5.65; F, 10.31; N, 10.14; O, 8.69


Synonym: DDR1-IN-1; DDR1-IN 1; DDR1-IN1.

IUPAC/Chemical Name: 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide

SMILES Code: FC(C1=CC(C(NC2=CC=C(C(OC3=CC(C4)=C(C=C3)NC4=O)=C2)C)=O)=CC=C1CN5CCN(CC)CC5)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. Structural mechanisms
determining inhibition of the collagen receptor DDR1 by selective and
multi-targeted type II kinase inhibitors. J Mol Biol. 2014 Jun
26;426(13):2457-70. doi: 10.1016/j.jmb.2014.04.014. Epub 2014 Apr 23. PubMed
PMID: 24768818; PubMed Central PMCID: PMC4058747.

2: Kim HG, Tan L, Weisberg EL, Liu F, Canning P, Choi HG, Ezell SA, Wu H, Zhao Z,
Wang J, Mandinova A, Griffin JD, Bullock AN, Liu Q, Lee SW, Gray NS. Discovery of
a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol.
2013 Oct 18;8(10):2145-50. doi: 10.1021/cb400430t. Epub 2013 Aug 13. Erratum in:
ACS Chem Biol. 2014 Mar 21;9(3):840. PubMed PMID: 23899692; PubMed Central PMCID:
PMC3800496.