Nitazoxanide
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MedKoo CAT#: 318369

CAS#: 55981-09-4

Description: Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths. Emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.


Price and Availability

Size Price Shipping out time Quantity
1g USD 150 Same day
2g USD 250 Same day
5g USD 450 Same day
25g USD 750 2 Weeks
100g USD 1250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-23. Prices are subject to change without notice.

Nitazoxanide, purity > 98%, is in stock. The same day shipping after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318369
Name: Nitazoxanide
CAS#: 55981-09-4
Chemical Formula: C12H9N3O5S
Exact Mass: 307.0263
Molecular Weight: 307.282
Elemental Analysis: C, 46.90; H, 2.95; N, 13.67; O, 26.03; S, 10.44


Synonym: Nitazoxanide, Alinia, Colufase, Daxon, Nitazoxamide

IUPAC/Chemical Name: [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

InChi Key: YQNQNVDNTFHQSW-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

SMILES Code: CC(OC1=CC=CC=C1C(NC2=NC=C([N+]([O-])=O)S2)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Di Santo N, Ehrisman J. A functional perspective of nitazoxanide as a potential anticancer drug. Mutat Res. 2014 Oct;768:16-21. doi: 10.1016/j.mrfmmm.2014.05.005. Epub 2014 Jun 2. Review. PubMed PMID: 25847384.

2: Rossignol JF. Nitazoxanide: a first-in-class broad-spectrum antiviral agent. Antiviral Res. 2014 Oct;110:94-103. doi: 10.1016/j.antiviral.2014.07.014. Epub 2014 Aug 7. Review. PubMed PMID: 25108173.

3: Nikolova K, Gluud C, Grevstad B, Jakobsen JC. Nitazoxanide for chronic hepatitis C. Cochrane Database Syst Rev. 2014 Apr 6;4:CD009182. doi: 10.1002/14651858.CD009182.pub2. Review. PubMed PMID: 24706397.

4: Pérez-Molina JA, Díaz-Menéndez M, Gallego JI, Norman F, Monge-Maillo B, Ayala AP, López-Vélez R. Evaluation of nitazoxanide for the treatment of disseminated cystic echinococcosis: report of five cases and literature review. Am J Trop Med Hyg. 2011 Feb;84(2):351-6. doi: 10.4269/ajtmh.2011.10-0513. Review. PubMed PMID: 21292913; PubMed Central PMCID: PMC3029196.

5: Bojar H, Knap JP. [Nitazoxanide ("Alinia")--a promising antiparasitic drug]. Wiad Parazytol. 2010;56(1):11-8. Review. Polish. PubMed PMID: 20450003.

6: Sud B, Salvaggio M, Greenfield R, Bronze MS. Part XI. Trimethoprim-sulfamethoxazole, nitrofurantoin, chloramphenicol, metronidazole and tinidazole, rifaximin, and nitazoxanide. J Okla State Med Assoc. 2007 Jul;100(7):267-72. Review. Erratum in: J Okla State Med Assoc. 2007 Oct;100(10):405. Greenfield, Ronald A [corrected to Greenfield, Ronald]. PubMed PMID: 17896614.

7: Anderson VR, Curran MP. Nitazoxanide: a review of its use in the treatment of gastrointestinal infections. Drugs. 2007;67(13):1947-67. Review. PubMed PMID: 17722965.

8: Hemphill A, Mueller J, Esposito M. Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert Opin Pharmacother. 2006 May;7(7):953-64. Review. PubMed PMID: 16634717.

9: Cohen SA. Use of nitazoxanide as a new therapeutic option for persistent diarrhea: a pediatric perspective. Curr Med Res Opin. 2005 Jul;21(7):999-1004. Review. PubMed PMID: 16004666.

10: White CA Jr. Nitazoxanide: a new broad spectrum antiparasitic agent. Expert Rev Anti Infect Ther. 2004 Feb;2(1):43-9. Review. PubMed PMID: 15482170.

11: Bailey JM, Erramouspe J. Nitazoxanide treatment for giardiasis and cryptosporidiosis in children. Ann Pharmacother. 2004 Apr;38(4):634-40. Epub 2004 Feb 27. Review. PubMed PMID: 14990779.