Nisoldipine
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Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318368

CAS#: 63675-72-9

Description: Nisoldipine is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 110 2 Weeks
100mg USD 190 2 Weeks
200mg USD 350 2 Weeks
500mg USD 550 2 Weeks
1g USD 750 2 Weeks
2g USD 1050 2 Weeks
5g USD 1950 2 Weeks
10g USD 2450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-25. Prices are subject to change without notice.

Nisoldipine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318368
Name: Nisoldipine
CAS#: 63675-72-9
Chemical Formula: C20H24N2O6
Exact Mass: 388.1634
Molecular Weight: 388.4144
Elemental Analysis: C, 61.84; H, 6.23; N, 7.21; O, 24.71


Synonym: Nisoldipine, Bay K 5552, Sular, Baymycard, Nisocor, Syscor

IUPAC/Chemical Name: 3-isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: VKQFCGNPDRICFG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3

SMILES Code: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: White WB. Pharmacologic agents in the management of hypertension--nisoldipine coat-core. J Clin Hypertens (Greenwich). 2007 Apr;9(4):259-66. Review. PubMed PMID: 17396068.

2: Hamilton SF, Houle LM, Thadani U. Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure. Heart Dis. 1999 Nov-Dec;1(5):279-88. Review. PubMed PMID: 11720635.

3: Heinig R. Clinical pharmacokinetics of nisoldipine coat-core. Clin Pharmacokinet. 1998 Sep;35(3):191-208. Review. Erratum in: Clin Pharmacokinet 1998 Nov;35(5):390. PubMed PMID: 9784933.

4: Opie LH. What does nisoldipine coat core (CC) add to current therapy that is clinically meaningful? Am J Cardiol. 1997 May 22;79(10A):29-32; discussion 47-8. Review. PubMed PMID: 9186064.

5: Langtry HD, Spencer CM. Nisoldipine coat-core. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of ischaemic heart disease. Drugs. 1997 May;53(5):867-84. Review. PubMed PMID: 9129871.

6: Fodor JG. Nisoldipine CC: efficacy and tolerability in hypertension and ischemic heart disease. Cardiovasc Drugs Ther. 1997 Jan;10 Suppl 3:873-9. Review. PubMed PMID: 9126676.

7: Langan J, Rodríguez-Mañas L, Sareli P, Heinig R. Nisoldipine CC: clinical experience in hypertension. Cardiology. 1997;88 Suppl 1:56-62; discussion 63-5. Review. PubMed PMID: 9118169.

8: Lewis BS. Efficacy and safety of nisoldipine coat core in the management of angina pectoris, systemic hypertension, and ischemic ventricular dysfunction. Am J Cardiol. 1995 Apr 27;75(13):46E-53E. Review. PubMed PMID: 7726125.

9: Pouleur H, Rousseau MF. Nisoldipine in severe ischaemic left ventricular dysfunction. Eur Heart J. 1993 Jul;14 Suppl A:45-7. Review. PubMed PMID: 8370362.

10: Mitchell J, Frishman W, Heiman M. Nisoldipine: a new dihydropyridine calcium-channel blocker. J Clin Pharmacol. 1993 Jan;33(1):46-52. Review. PubMed PMID: 8429113.

11: Eber B, Schumacher M, Zweiker R, Pokan R, Klein W. [Nisoldipine in comparison with long-term nitrates]. Acta Med Austriaca. 1992;19(5):137-9. Review. German. PubMed PMID: 1298142.

12: Duncker DJ, Van Woerkens LJ, Serruys PW, Roelandt JR, Hugenholtz PG, Verdouw PD. Actions of nisoldipine in cardiovascular disease. Can J Cardiol. 1989 Jun-Aug;5(5):266-74. Review. PubMed PMID: 2667729.

13: Friedel HA, Sorkin EM. Nisoldipine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of angina pectoris, hypertension and related cardiovascular disorders. Drugs. 1988 Dec;36(6):682-731. Review. PubMed PMID: 3065058.

14: Melcher A, Dens J, Curry P, Hagel H. Nisoldipine CC: clinical experience in ischaemic heart disease. Cardiology. 1997;88 Suppl 1:17-23; discussion 24-5. Review. PubMed PMID: 9118164.

15: Plosker GL, Faulds D. Nisoldipine coat-core. A review of its pharmacology and therapeutic efficacy in hypertension. Drugs. 1996 Aug;52(2):232-53. Review. PubMed PMID: 8841741.

16: Glasser SP. Nisoldipine coat core as concomitant therapy in chronic stable angina pectoris. Am J Cardiol. 1995 Apr 27;75(13):68E-70E. Review. PubMed PMID: 7726128.

17: Zannad F. Clinical pharmacology of nisoldipine coat core. Am J Cardiol. 1995 Apr 27;75(13):41E-45E. Review. PubMed PMID: 7726124.

18: Knorr AM. Why is nisoldipine a specific agent in ischemic left ventricular dysfunction? Am J Cardiol. 1995 Apr 27;75(13):36E-40E. Review. PubMed PMID: 7726122.

19: Krivonkin KIu, Belousov IuB. [Clinical pharmacology of nisoldipine, a new calcium antagonist]. Kardiologiia. 1991 Sep;31(9):100-5. Review. Russian. PubMed PMID: 1753601.

20: Knorr A. The pharmacology of nisoldipine. Cardiovasc Drugs Ther. 1987 Dec;1(4):393-402. Review. PubMed PMID: 3154674.