ML337 | CAS#1443118-44-2 | mGlu3 NAMs

ML337
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526622

CAS#: 1443118-44-2

Description: ML337 is a highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration. ML337 resulted (mGlu3 IC50 = 593 nM, mGlu2 IC50 >30 μM) with B:P ratios of 0.92 (mouse) to 0.3 (rat). ML337 possesses favorable physiochemical properties, a good dystrophia myotonica protein kinase (DMPK) profile and is centrally penetrant. Thus, ML337 is a best-in-class in vitro and in vivo probe for studying non-competitive antagonism of mGlu3.

Chemical Structure

ML337

CAS# 1443118-44-2

Instruction

Theoretical Analysis

MedKoo Cat#: 526622
Name: ML337
CAS#: 1443118-44-2
Chemical Formula: C21H20FNO3
Exact Mass: 353.14
Molecular Weight: 353.393
Elemental Analysis: C, 71.37; H, 5.70; F, 5.38; N, 3.96; O, 13.58

Price and Availability

Size	Price	Availability
25mg	USD 450	2 Weeks
50mg	USD 750	2 Weeks
100mg	USD 1350	2 Weeks
200mg	USD 2150	2 Weeks
500mg	USD 3250	2 Weeks
1g	USD 4650	2 Weeks
2g	USD 7450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ML-337; ML 337; ML337.

IUPAC/Chemical Name: (R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone

InChi Key: QBCRLDPMQHPGIM-QGZVFWFLSA-N

InChi Code: InChI=1S/C21H20FNO3/c1-26-18-9-6-15(7-10-18)4-5-16-8-11-19(20(22)13-16)21(25)23-12-2-3-17(24)14-23/h6-11,13,17,24H,2-3,12,14H2,1H3/t17-/m1/s1

SMILES Code: O=C(C1=CC=C(C#CC2=CC=C(OC)C=C2)C=C1F)N3C[C@H](O)CCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wenthur C, Daniels JS, Morrison R, Engers JL, Niswender CM, Conn PJ, Lindsley
CW. Development of a Second Generation mGlu(3) NAM Probe. 2012 Dec 10 [updated
2013 Mar 22]. Probe Reports from the NIH Molecular Libraries Program [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Available from http://www.ncbi.nlm.nih.gov/books/NBK148852/
PubMed PMID: 23885366.

2: Wenthur CJ, Morrison R, Felts AS, Smith KA, Engers JL, Byers FW, Daniels JS,
Emmitte KA, Conn PJ, Lindsley CW. Discovery of
(R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl)
(3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant
negative allosteric modulator (NAM). J Med Chem. 2013 Jun 27;56(12):5208-12. doi:
10.1021/jm400439t. Epub 2013 Jun 13. PubMed PMID: 23718281; PubMed Central PMCID:
PMC3769689.

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