WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 524212
Description: AMG-222, also known as ALS-2-0426, ALS-20426, is a DPP-4 inhibitor potentially for the treatment of type 2 diabetes.
MedKoo Cat#: 524212
Chemical Formula: C32H39N9O3
Exact Mass: 597.31759
Molecular Weight: 597.71
Elemental Analysis: C, 64.30; H, 6.58; N, 21.09; O, 8.03
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: AMG-222; AMG 222; AMG222; ALS-2-0426 free base; ALS-2-0426; ALS-20426.
IUPAC/Chemical Name: 5H-Dibenzo(a,d)cycloheptene-2,8-dicarboxamide, 5-((2S)-2-((2-((2S)-2-cyano-1-pyrrolidinyl)-2-oxoethyl)amino)propyl)-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-
InChi Key: NVSWJKWHLUTHLP-CPJSRVTESA-N
InChi Code: InChI=1S/C32H39N9O3/c1-20(34-19-28(42)41-14-6-7-25(41)18-33)17-32(31-35-37-38-36-31)26-12-10-23(29(43)39(2)3)15-21(26)8-9-22-16-24(11-13-27(22)32)30(44)40(4)5/h10-13,15-16,20,25,34H,6-9,14,17,19H2,1-5H3,(H,35,36,37,38)/t20-,25-/m0/s1
SMILES Code: C[C@@H](CC1(c2ccc(cc2CCc3c1ccc(c3)C(=O)N(C)C)C(=O)N(C)C)c4[nH]nnn4)NCC(=O)N5CCC[C@H]5C#N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 597.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kiang YH, Cheung E, Stephens PW, Nagapudi K. Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods. J Pharm Sci. 2014 Sep;103(9):2809-18. doi: 10.1002/jps.23873. Epub 2014 Jan 27. PubMed PMID: 24470123.
2: Kiang YH, Nagapudi K, Liu J, Staples RJ, Jona J. Crystal structure study and investigation of solid-state cyclization for AMG 222, a channel hydrate. Int J Pharm. 2013 Jan 30;441(1-2):299-306. doi: 10.1016/j.ijpharm.2012.11.029. Epub 2012 Nov 23. PubMed PMID: 23182974.
3: Greene RJ, Tu H, Gibbs JP, Greg Slatter J. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222. Xenobiotica. 2011 Nov;41(11):945-57. doi: 10.3109/00498254.2011.597455. Epub 2011 Aug 25. PubMed PMID: 21867423.