AMG-222

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524212

CAS#: 913978-37-7

Description: AMG-222, also known as ALS-2-0426, ALS-20426, is a DPP-4 inhibitor potentially for the treatment of type 2 diabetes.


Chemical Structure

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AMG-222
CAS# 913978-37-7

Theoretical Analysis

MedKoo Cat#: 524212
Name: AMG-222
CAS#: 913978-37-7
Chemical Formula: C32H39N9O3
Exact Mass: 597.31759
Molecular Weight: 597.71
Elemental Analysis: C, 64.30; H, 6.58; N, 21.09; O, 8.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AMG-222; AMG 222; AMG222; ALS-2-0426 free base; ALS-2-0426; ALS-20426.

IUPAC/Chemical Name: 5H-Dibenzo(a,d)cycloheptene-2,8-dicarboxamide, 5-((2S)-2-((2-((2S)-2-cyano-1-pyrrolidinyl)-2-oxoethyl)amino)propyl)-10,11-dihydro-N2,N2,N8,N8-tetramethyl-5-(2H-tetrazol-5-yl)-

InChi Key: NVSWJKWHLUTHLP-CPJSRVTESA-N

InChi Code: InChI=1S/C32H39N9O3/c1-20(34-19-28(42)41-14-6-7-25(41)18-33)17-32(31-35-37-38-36-31)26-12-10-23(29(43)39(2)3)15-21(26)8-9-22-16-24(11-13-27(22)32)30(44)40(4)5/h10-13,15-16,20,25,34H,6-9,14,17,19H2,1-5H3,(H,35,36,37,38)/t20-,25-/m0/s1

SMILES Code: C[C@@H](CC1(c2ccc(cc2CCc3c1ccc(c3)C(=O)N(C)C)C(=O)N(C)C)c4[nH]nnn4)NCC(=O)N5CCC[C@H]5C#N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 597.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kiang YH, Cheung E, Stephens PW, Nagapudi K. Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods. J Pharm Sci. 2014 Sep;103(9):2809-18. doi: 10.1002/jps.23873. Epub 2014 Jan 27. PubMed PMID: 24470123.

2: Kiang YH, Nagapudi K, Liu J, Staples RJ, Jona J. Crystal structure study and investigation of solid-state cyclization for AMG 222, a channel hydrate. Int J Pharm. 2013 Jan 30;441(1-2):299-306. doi: 10.1016/j.ijpharm.2012.11.029. Epub 2012 Nov 23. PubMed PMID: 23182974.

3: Greene RJ, Tu H, Gibbs JP, Greg Slatter J. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222. Xenobiotica. 2011 Nov;41(11):945-57. doi: 10.3109/00498254.2011.597455. Epub 2011 Aug 25. PubMed PMID: 21867423.