WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 524209
Description: AMG-126737 is a potent inhibitor of human lung mast cell tryptase with greater than 10- to 200-fold selectivity versus other serine proteases. AMG-126737 has potential therapeutic utility in pulmonary disorders.
MedKoo Cat#: 524209
Chemical Formula: C33H38N6O6S2
Exact Mass: 678.22942
Molecular Weight: 678.82
Elemental Analysis: C, 58.39; H, 5.64; N, 12.38; O, 14.14; S, 9.45
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: AMG-126737; AMG 126737; AMG126737; 105RSZ5CNS; SCHEMBL7986111; AMG 126737; UNII-105RSZ5CNS;
IUPAC/Chemical Name: Benzenecarboximidamide, 3,3'-(1,5-pentanediylbis(oxy-4,1-phenylenemethyleneiminosulfonyl))bis-
InChi Key: CTLMBCYIAXNYOG-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H38N6O6S2/c34-32(35)26-6-4-8-30(20-26)46(40,41)38-22-24-10-14-28(15-11-24)44-18-2-1-3-19-45-29-16-12-25(13-17-29)23-39-47(42,43)31-9-5-7-27(21-31)33(36)37/h4-17,20-21,38-39H,1-3,18-19,22-23H2,(H3,34,35)(H3,36,37)
SMILES Code: c1cc(cc(c1)S(=O)(=O)NCc2ccc(cc2)OCCCCCOc3ccc(cc3)CNS(=O)(=O)c4cccc(c4)C(=N)N)C(=N)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 678.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wright CD, Havill AM, Middleton SC, Kashem MA, Dripps DJ, Abraham WM, Thomson DS, Burgess LE. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737). Biochem Pharmacol. 1999 Dec 15;58(12):1989-96. PubMed PMID: 10591155.