AMG-126737

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524209

CAS#: 224054-76-6

Description: AMG-126737 is a potent inhibitor of human lung mast cell tryptase with greater than 10- to 200-fold selectivity versus other serine proteases. AMG-126737 has potential therapeutic utility in pulmonary disorders.


Chemical Structure

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AMG-126737
CAS# 224054-76-6

Theoretical Analysis

MedKoo Cat#: 524209
Name: AMG-126737
CAS#: 224054-76-6
Chemical Formula: C33H38N6O6S2
Exact Mass: 678.22942
Molecular Weight: 678.82
Elemental Analysis: C, 58.39; H, 5.64; N, 12.38; O, 14.14; S, 9.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AMG-126737; AMG 126737; AMG126737; 105RSZ5CNS; SCHEMBL7986111; AMG 126737; UNII-105RSZ5CNS;

IUPAC/Chemical Name: Benzenecarboximidamide, 3,3'-(1,5-pentanediylbis(oxy-4,1-phenylenemethyleneiminosulfonyl))bis-

InChi Key: CTLMBCYIAXNYOG-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H38N6O6S2/c34-32(35)26-6-4-8-30(20-26)46(40,41)38-22-24-10-14-28(15-11-24)44-18-2-1-3-19-45-29-16-12-25(13-17-29)23-39-47(42,43)31-9-5-7-27(21-31)33(36)37/h4-17,20-21,38-39H,1-3,18-19,22-23H2,(H3,34,35)(H3,36,37)

SMILES Code: c1cc(cc(c1)S(=O)(=O)NCc2ccc(cc2)OCCCCCOc3ccc(cc3)CNS(=O)(=O)c4cccc(c4)C(=N)N)C(=N)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 678.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wright CD, Havill AM, Middleton SC, Kashem MA, Dripps DJ, Abraham WM, Thomson DS, Burgess LE. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737). Biochem Pharmacol. 1999 Dec 15;58(12):1989-96. PubMed PMID: 10591155.