AM-1714

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524176

CAS#: 335371-37-4

Description: AM-1714 is a drug that acts as a reasonably selective agonist of the peripheral cannabinoid receptor CB2. In animal studies it has both analgesic and anti-allodynia effects.


Chemical Structure

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AM-1714
CAS# 335371-37-4

Theoretical Analysis

MedKoo Cat#: 524176
Name: AM-1714
CAS#: 335371-37-4
Chemical Formula: C22H26O4
Exact Mass: 354.18311
Molecular Weight: 354.44
Elemental Analysis: C, 74.55; H, 7.39; O, 18.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AM-1714; AM 1714; AM1714; UNII-E3OY6PCU04;

IUPAC/Chemical Name: 6H-Dibenzo(b,d)pyran-6-one, 3-(1,1-dimethylheptyl)-1,9-dihydroxy-

InChi Key: BWKBVEVEQOCSCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H26O4/c1-4-5-6-7-10-22(2,3)14-11-18(24)20-17-13-15(23)8-9-16(17)21(25)26-19(20)12-14/h8-9,11-13,23-24H,4-7,10H2,1-3H3

SMILES Code: CCCCCCC(C)(C)c1cc(c2c3cc(ccc3c(=O)oc2c1)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 354.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Rahn EJ, Zvonok AM, Thakur GA, Khanolkar AD, Makriyannis A, Hohmann AG. Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. J Pharmacol Exp Ther. 2008 Nov;327(2):584-91. doi: 10.1124/jpet.108.141994. Epub 2008 Jul 29. PubMed PMID: 18664590; PubMed Central PMCID: PMC2682949.

2: Khanolkar AD, Lu D, Ibrahim M, Duclos RI Jr, Thakur GA, Malan TP Jr, Porreca F, Veerappan V, Tian X, George C, Parrish DA, Papahatjis DP, Makriyannis A. Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. Epub 2007 Nov 27. PubMed PMID: 18038967.

3: Mukherjee S, Adams M, Whiteaker K, Daza A, Kage K, Cassar S, Meyer M, Yao BB. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. Eur J Pharmacol. 2004 Nov 28;505(1-3):1-9. PubMed PMID: 15556131.