AM-114
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524169

CAS#: 856849-35-9

Description: AM 114 is a proteasome inhibitor. It is an inhibitor of chymotrypsin-like activity of the 20S proteasome. Also, AM-114 displays anticancer activity, inhibits cell growth in human colon cancer HCT116 p53+/+ cells.


Chemical Structure

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AM-114
CAS# 856849-35-9

Theoretical Analysis

MedKoo Cat#: 524169
Name: AM-114
CAS#: 856849-35-9
Chemical Formula: C20H21B2NO5
Exact Mass: 377.16058
Molecular Weight: 377.01
Elemental Analysis: C, 63.72; H, 5.61; B, 5.74; N, 3.72; O, 21.22

Price and Availability

Size Price Availability Quantity
10.0mg USD 330.0 2 Weeks
50.0mg USD 1075.0 2 Weeks
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Synonym: AM-114; AM 114; AM114; Proteasome Inhibitor IX;

IUPAC/Chemical Name: ((1Z,1'Z)-(1-methyl-4-oxopiperidine-3,5-diylidene)bis(methanylylidene))bis(4,1-phenylene))diboronic acid

InChi Key: SRPIKXGUPAKTIZ-APGQMXJTSA-N

InChi Code: InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10-,17-11-

SMILES Code: B(O)(O)c1ccc(cc1)/C=C/2\C(=O)/C(=C\c3ccc(cc3)B(O)O)/CN(C2)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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AM-114

10.0mg / USD 330.0