AG 879
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MedKoo CAT#: 524142

CAS#: 148741-30-4

Description: AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2850 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

AG 879, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 524142
Name: AG 879
CAS#: 148741-30-4
Chemical Formula: C18H24N2OS
Exact Mass: 316.16093
Molecular Weight: 316.46
Elemental Analysis: C, 68.32; H, 7.64; N, 8.85; O, 5.06; S, 10.13


Synonym: AG 879; AG879; AG-879; Tyrphostin AG 879;

IUPAC/Chemical Name: 2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

InChi Key: XRZYELWZLNAXGE-KPKJPENVSA-N

InChi Code: InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

SMILES Code: S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Larsson LI. Novel actions of tyrphostin AG 879: inhibition of RAF-1 and HER-2

expression combined with strong antitumoral effects on breast cancer cells. Cell

Mol Life Sci. 2004 Oct;61(19-20):2624-31. PubMed PMID: 15526167.

2: He H, Hirokawa Y, Manser E, Lim L, Levitzki A, Maruta H. Signal therapy for

RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for

ErbB2 and Src family kinases, that block PAK activation. Cancer J. 2001

May-Jun;7(3):191-202. PubMed PMID: 11419027.