WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524117

CAS#: 676559-83-4

Description: ABT-279 is a bio-active chemical.

Price and Availability




ABT-279, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 524117
Name: ABT-279
CAS#: 676559-83-4
Chemical Formula: C21H25N5O3
Exact Mass: 395.19574
Molecular Weight: 395.45
Elemental Analysis: C, 63.78; H, 6.37; N, 17.71; O, 12.14

Synonym: ABT-279; ABT 279; ABT279;

IUPAC/Chemical Name: 4-Pyridinecarboxylic acid, 2-(4-((2-((2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-


InChi Code: InChI=1S/C21H25N5O3/c1-3-16-4-5-17(13-22)26(16)19(27)14-24-21(2)7-10-25(11-8-21)18-12-15(20(28)29)6-9-23-18/h1,6,9,12,16-17,24H,4-5,7-8,10-11,14H2,2H3,(H,28,29)/t16-,17-/m0/s1

SMILES Code: CC1(CCN(CC1)c2cc(ccn2)C(=O)O)NCC(=O)N3[C@H](CC[C@H]3C#N)C#C

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Gilibili RR, Bhamidipati RK, Mullangi R, Srinivas NR. Retrospective and

Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl

peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of

ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin. J Pharm

Pharm Sci. 2015;18(3):434-48. PubMed PMID: 26517136.

2: Havale SH, Pal M. Medicinal chemistry approaches to the inhibition of

dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem.

2009 Mar 1;17(5):1783-802. doi: 10.1016/j.bmc.2009.01.061. Epub 2009 Jan 31.

Review. PubMed PMID: 19217790.

3: Kim J, Flick J, Reimer MT, Rodila R, Wang PG, Zhang J, Ji QC, El-Shourbagy TA.

LC-MS/MS determination of


peridinyl)-4-pyridinecarboxylic acid (ABT-279) in dog plasma with high-throughput

protein precipitation sample preparation. Biomed Chromatogr. 2007

Nov;21(11):1118-26. PubMed PMID: 17590862.

4: Zhang J, Kim EJ, Ji QC, El-Shourbagy TA. Developing multiple high-throughput

GLP methods for an investigational drug candidate in various matrices within a

96-well plate. Rapid Commun Mass Spectrom. 2006;20(24):3755-60. PubMed PMID:


5: Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, Von

Geldern TW, Fickes MG, Bhagavatula L, McDermott T, Wittenberger S, Richards SJ,

Longenecker KL, Stewart KD, Lubben TH, Ballaron SJ, Stashko MA, Long MA, Wells H,

Zinker BA, Mika AK, Beno DW, Kempf-Grote AJ, Polakowski J, Segreti J, Reinhart

GA, Fryer RM, Sham HL, Trevillyan JM. Discovery of


4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent,

selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV,

useful for the treatment of diabetes. J Med Chem. 2006 Oct 19;49(21):6416-20.

PubMed PMID: 17034148.