WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 524115
CAS#: 181141-52-6; 186293-38-9 (ABT-255 free base);
Description: ABT-255 is a novel 2-pyridone antibacterial agent which demonstrates in vitro potency and in vivo efficacy against drug-susceptible and drug-resistant M. tuberculosis strains. It is used as therapy for pulmonary tuberculosis.
MedKoo Cat#: 524115
Name: ABT-255
CAS#: 181141-52-6; 186293-38-9 (ABT-255 free base);
Chemical Formula: C21H25ClFN3O3
Exact Mass:
Molecular Weight: 421.89
Elemental Analysis: C, 59.78; H, 5.97; Cl, 8.40; F, 4.50; N, 9.96; O, 11.38
This product is not in stock, which may be available by custom synthesis.
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Synonym: ABT-255; ABT 255; ABT255; UNII-YA04O24J4T;
IUPAC/Chemical Name: 1-cyclopropyl-7-fluoro-8-((4aS,7aS)-hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride
InChi Key: UTKJBXOVMQXMOU-OZIFAFRSSA-N
InChi Code: InChI=1S/C21H24FN3O3.ClH/c1-11-18-14(12-4-5-12)7-15(21(27)28)20(26)25(18)9-16(22)19(11)24-8-13-3-2-6-23-17(13)10-24;/h7,9,12-13,17,23H,2-6,8,10H2,1H3,(H,27,28);1H/t13-,17+;/m0./s1
SMILES Code: O=C(C1=CC(C2CC2)=C3C(C)=C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)C(F)=CN3C1=O)O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2933.59.95 00
The following data is based on the product molecular weight 421.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Segreti JA, Polakowski JS, Koch KA, Marsh KC, Bauch JL, Rosenberg SH, Sham HL, Cox BF, Reinhart GA. Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study. Cancer Chemother Pharmacol. 2004 Sep;54(3):273-81. Epub 2004 Jun 2. PubMed PMID: 15173957.
2: Tomioka H. [Prospects for development of new antituberculous drugs]. Kekkaku. 2002 Aug;77(8):573-84. Japanese. PubMed PMID: 12235850.
3: Oleksijew A, Meulbroek J, Ewing P, Jarvis K, Mitten M, Paige L, Tovcimak A, Nukkula M, Chu D, Alder JD. In vivo efficacy of ABT-255 against drug-sensitive and -resistant Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Oct;42(10):2674-7. PubMed PMID: 9756775; PubMed Central PMCID: PMC105917.
