WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407421
Description: D-64131 is a potent and selective tubulin inhibitor. D-64131 inhibits tumor cell proliferation in vitro (IC50 = 74 nM). In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg.
MedKoo Cat#: 407421
Chemical Formula: C16H13NO2
Exact Mass: 251.0946
Molecular Weight: 251.285
Elemental Analysis: C, 76.48; H, 5.21; N, 5.57; O, 12.73
Synonym: D-64131; D 64131; D64131.
IUPAC/Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
InChi Key: ICMIJSRDISNKOC-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
SMILES Code: O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 251.285 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Putey A, Popowycz F, Do QT, Bernard P, Talapatra SK, Kozielski F, Galmarini
CM, Joseph B. Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives
as tubulin polymerization inhibitors: synthesis and structure--activity
relationship studies. J Med Chem. 2009 Oct 8;52(19):5916-25. doi:
10.1021/jm900476c. PubMed PMID: 19743863.
2: Beckers T, Reissmann T, Schmidt M, Burger AM, Fiebig HH, Vanhoefer U, Pongratz
H, Hufsky H, Hockemeyer J, Frieser M, Mahboobi S. 2-aroylindoles, a novel class
of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun
1;62(11):3113-9. PubMed PMID: 12036922.