FPS-ZM1
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MedKoo CAT#: 522717

CAS#: 945714-67-0

Description: FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE, neurological damage and inflammation in the APP(sw/0) transgenic mouse model of AD. FPS-ZM1 is not toxic to mice and can easily cross the blood-brain barrier. AGEs administration induced an-regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are significantly reduced by FPS-ZM1 treatment. FPS-ZM1 might be a novel therapeutic agent to treat AD patients.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 150 Same day
200mg USD 450 Same day
500mg USD 850 Same day
1g USD 1450 Same day
2g USD 2150 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

FPS-ZM1, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522717
Name: FPS-ZM1
CAS#: 945714-67-0
Chemical Formula: C20H22ClNO
Exact Mass: 327.139
Molecular Weight: 327.852
Elemental Analysis: C, 73.27; H, 6.76; Cl, 10.81; N, 4.27; O, 4.88


Synonym: FPS-ZM1; FPS ZM1; FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1;

IUPAC/Chemical Name: N-benzyl-4-chloro-N-cyclohexylbenzamide

InChi Key: XDFKWGIBQMHSOH-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2

SMILES Code: C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl


Technical Data

Appearance:
White Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hong Y, Shen C, Yin Q, Sun M, Ma Y, Liu X. Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem Res. 2016 May;41(5):1192-9. doi: 10.1007/s11064-015-1814-8. Epub 2016 Jan 6. PubMed PMID: 26738988.

2: Chen Y, Huang XJ, Yu N, Xie Y, Zhang K, Wen F, Liu H, Di Q. HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products. PLoS One. 2015 Oct 20;10(10):e0140918. doi: 10.1371/journal.pone.0140918. eCollection 2015. PubMed PMID: 26485677; PubMed Central PMCID: PMC4613137.

3: Li D, Lei C, Zhang S, Zhang S, Liu M, Wu B. Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage. Neurosci Lett. 2015 Nov 16;609:109-19. doi: 10.1016/j.neulet.2015.10.035. Epub 2015 Oct 23. PubMed PMID: 26483322.

4: Good DW, George T, Watts BA 3rd. High-mobility group box 1 inhibits HCO(3)(-) absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway. Am J Physiol Renal Physiol. 2015 Oct 15;309(8):F720-30. doi: 10.1152/ajprenal.00227.2015. Epub 2015 Jul 15. PubMed PMID: 26180239; PubMed Central PMCID: PMC4609918.

5: Sakamoto K, Mizuta A, Fujimura K, Kurauchi Y, Mori A, Nakahara T, Ishii K. High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina. Exp Eye Res. 2015 Aug;137:63-70. doi: 10.1016/j.exer.2015.06.003. Epub 2015 Jun 12. PubMed PMID: 26079740.

6: Dahrouj M, Desjardins DM, Liu Y, Crosson CE, Ablonczy Z. Receptor mediated disruption of retinal pigment epithelium function in acute glycated-albumin exposure. Exp Eye Res. 2015 Aug;137:50-6. doi: 10.1016/j.exer.2015.06.004. Epub 2015 Jun 10. PubMed PMID: 26070987; PubMed Central PMCID: PMC4523492.

7: Narumi K, Miyakawa R, Ueda R, Hashimoto H, Yamamoto Y, Yoshida T, Aoki K. Proinflammatory Proteins S100A8/S100A9 Activate NK Cells via Interaction with RAGE. J Immunol. 2015 Jun 1;194(11):5539-48. doi: 10.4049/jimmunol.1402301. Epub 2015 Apr 24. PubMed PMID: 25911757.

8: Lei C, Zhang S, Cao T, Tao W, Liu M, Wu B. HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage. Neuroscience. 2015 Jun 4;295:39-47. doi: 10.1016/j.neuroscience.2015.03.032. Epub 2015 Mar 23. PubMed PMID: 25813710.

9: Yang F, Wang Z, Zhang JH, Tang J, Liu X, Tan L, Huang QY, Feng H. Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage. Stroke. 2015 May;46(5):1328-36. doi: 10.1161/STROKEAHA.114.008336. Epub 2015 Mar 17. PubMed PMID: 25782468.

10: Yu T, Li L, Chen T, Liu Z, Liu H, Li Z. Erythropoietin attenuates advanced glycation endproducts-induced toxicity of Schwann cells in vitro. Neurochem Res. 2015 Apr;40(4):698-712. doi: 10.1007/s11064-015-1516-2. Epub 2015 Jan 14. PubMed PMID: 25585642.

11: Lei C, Wu B, Cao T, Zhang S, Liu M. Activation of the high-mobility group box 1 protein-receptor for advanced glycation end-products signaling pathway in rats during neurogenesis after intracerebral hemorrhage. Stroke. 2015 Feb;46(2):500-6. doi: 10.1161/STROKEAHA.114.006825. Epub 2014 Dec 23. PubMed PMID: 25538203.

12: Gu Q, Wang B, Zhang XF, Ma YP, Liu JD, Wang XZ. Contribution of receptor for advanced glycation end products to vasculature-protecting effects of exercise training in aged rats. Eur J Pharmacol. 2014 Oct 15;741:186-94. doi: 10.1016/j.ejphar.2014.08.017. Epub 2014 Aug 24. PubMed PMID: 25160740.

13: Meredith ME, Qu ZC, May JM. Ascorbate reverses high glucose- and RAGE-induced leak of the endothelial permeability barrier. Biochem Biophys Res Commun. 2014 Feb 28;445(1):30-5. doi: 10.1016/j.bbrc.2014.01.078. Epub 2014 Jan 25. PubMed PMID: 24472555; PubMed Central PMCID: PMC3955275.

14: Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr;122(4):1377-92. doi: 10.1172/JCI58642. Epub 2012 Mar 12. PubMed PMID: 22406537; PubMed Central PMCID: PMC3314449.

(Last updated: 4/20/2016)