WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318604

CAS#: 120138-50-3

Description: Quinupristin is an antibiotic, often used in combination with dalfopristin under the trade name Synercid. It is active against Gram-positive bacteria, atypical but not Gram negatives. They inhibit protein synthesis of the cells. Quinupristin & dalfopristin are not active against Enterococcus faecalis and they need to be given in combination with other antibacterials for mixed infections which also involve Gram negative organisms.

Price and Availability


USD 450


Quinupristin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318604
Name: Quinupristin
CAS#: 120138-50-3
Chemical Formula: C53H67N9O10S
Exact Mass: 1021.47316
Molecular Weight: 1022.22
Elemental Analysis: C, 62.27; H, 6.61; N, 12.33; O, 15.65; S, 3.14

Synonym: Quinupristin; RP 68888; RP-68888; RP68888; RP-57669; RP 57669; RP57669; Antibiotic RP 57669; Quinupristin.

IUPAC/Chemical Name: N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(4-(dimethylamino)benzyl)-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-((((S)-quinuclidin-3-yl)thio)methyl)docosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1]oxa[4,7,10,13,16]pentaazacyclononadecin-9-yl)-3-hydroxypicolinamide


InChi Code: InChI=1S/C53H67N9O10S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65)/t31-,35+,37-,38+,39+,40+,43-,44+,45+/m1/s1

SMILES Code: O=C(N[C@@H]1C(N[C@H](CC)C(N2[C@](CCC2)([H])C(N(C)[C@@H](CC3=CC=C(N(C)C)C=C3)C(N4[C@](CC([C@H](CS[C@@H]5CN6CCC5CC6)C4)=O)([H])C(N[C@@H](C7=CC=CC=C7)C(O[C@@H]1C)=O)=O)=O)=O)=O)=O)C8=NC=CC=C8O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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Glycopeptide-Resistant Enterococci to Linezolid, Quinupristin/dalfopristin,
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2: Yu F, Lu C, Liu Y, Sun H, Shang Y, Ding Y, Li D, Qin Z, Parsons C, Huang X, Li
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3: You YH, Wang HB, Tao XX, Song YY, Meng FL, Yan XM, Luo FJ, Zhang JZ.
Antimicrobial susceptibility of Streptococcus sp. to quinupristin-dalfopristin in
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resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese
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5: Kali A, Stephen S, Umadevi S, Kumar S. Detection of quinupristin-dalfopristin
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6: Stroh EM. Quinupristin/dalfopristin in vancomycin-resistant Staphylococcus
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7: Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infection:
vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin,
telavancin, and ceftaroline. Med Clin North Am. 2011 Jul;95(4):723-42, vii. doi:
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8: Hernandez-Da Mota SE. Quinupristin/dalfopristin in Staphylococcus aureus
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9: Hwang IY, Ku HO, Lim SK, Lee KJ, Park CK, Jung GS, Jung SC, Park YH, Nam HM.
Distribution of streptogramin resistance genes and genetic relatedness among
quinupristin/dalfopristin-resistant Enterococcus faecium recovered from pigs and
chickens in Korea. Res Vet Sci. 2010 Aug;89(1):1-4. doi:
10.1016/j.rvsc.2010.01.011. Epub 2010 Mar 5. PubMed PMID: 20206952.

10: Chong YP, Lee SO, Song EH, Lee EJ, Jang EY, Kim SH, Choi SH, Kim MN, Jeong
JY, Woo JH, Kim YS. Quinupristin-dalfopristin versus linezolid for the treatment
of vancomycin-resistant Enterococcus faecium bacteraemia: efficacy and
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11: Baudoux P, Lemaire S, Denis O, Tulkens PM, Van Bambeke F, Glupczynski Y.
Activity of quinupristin/dalfopristin against extracellular and intracellular
Staphylococcus aureus with various resistance phenotypes. J Antimicrob Chemother.
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12: López F, Culebras E, Betriú C, Rodríguez-Avial I, Gómez M, Picazo JJ.
Antimicrobial susceptibility and macrolide resistance genes in Enterococcus
faecium with reduced susceptibility to quinupristin-dalfopristin: level of
quinupristin-dalfopristin resistance is not dependent on erm(B) attenuator region
sequence. Diagn Microbiol Infect Dis. 2010 Jan;66(1):73-7. doi:
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resistance selection after exposure to teicoplanin, vancomycin, linezolid and
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16: Nam HR, Lee HM, Lee Y. Isolation of quinupristin/dalfopristin-resistant
Streptococcus agalactiae from asymptomatic Korean women. J Microbiol. 2008
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17: Barthel D, Schlitzer M, Pradel G. Telithromycin and quinupristin-dalfopristin
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18: Lee do K, Kim Y, Park KS, Yang JW, Kim K, Ha NJ. Antimicrobial activity of
mupirocin, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline
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19: Jørgen B, Merckoll P, Melby KK. Susceptibility to daptomycin,
quinupristin-dalfopristin and linezolid and some other antibiotics in clinical
isolates of methicillin resistant and methicillin sensitive S.aureus from the
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20: Młynarczyk G, Młynarczyk A, Szymanek K, Bilewska A, Pupek J, Luczak M. [MIC
and MBC of quinupristin/dalfopristin of erythromycin-resistant MRSA strains
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