MS417
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407402

CAS#: 916489-36-6

Description: MS417, also known as GTPL7512, is a potent and selective BRD4 inhibitor. MS417 inhibits colorectal cancer growth and metastasis. Treatment with inhibitor MS417 potently affects cancer cells, although such effects were not always outright necrosis or apoptosis.


Chemical Structure

img
MS417
CAS# 916489-36-6

Theoretical Analysis

MedKoo Cat#: 407402
Name: MS417
CAS#: 916489-36-6
Chemical Formula: C20H19ClN4O2S
Exact Mass: 414.0917
Molecular Weight: 414.908
Elemental Analysis: C, 57.90; H, 4.62; Cl, 8.54; N, 13.50; O, 7.71; S, 7.73

Price and Availability

Size Price Availability Quantity
5.0mg USD 280.0 2 Weeks
25.0mg USD 850.0 2 Weeks
Bulk inquiry

Synonym: MS417; MS-417; MS 417; GTPL7512; GTPL-7512; GTPL 7512.

IUPAC/Chemical Name: methyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

InChi Key: GGRCIHACOIMRKY-HNNXBMFYSA-N

InChi Code: InChI=1S/C20H19ClN4O2S/c1-10-11(2)28-20-17(10)18(13-5-7-14(21)8-6-13)22-15(9-16(26)27-4)19-24-23-12(3)25(19)20/h5-8,15H,9H2,1-4H3/t15-/m0/s1

SMILES Code: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC)C4=CC=C(C=C4)Cl)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 414.908 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hu Y, Zhou J, Ye F, Xiong H, Peng L, Zheng Z, Xu F, Cui M, Wei C, Wang X, Wang Z, Zhu H, Lee P, Zhou M, Jiang B, Zhang DY. BRD4 inhibitor inhibits colorectal cancer growth and metastasis. Int J Mol Sci. 2015 Jan 16;16(1):1928-48. doi: 10.3390/ijms16011928. PubMed PMID: 25603177; PubMed Central PMCID: PMC4307342.

2: Liu R, Zhong Y, Li X, Chen H, Jim B, Zhou MM, Chuang PY, He JC. Role of transcription factor acetylation in diabetic kidney disease. Diabetes. 2014 Jul;63(7):2440-53. doi: 10.2337/db13-1810. Epub 2014 Mar 7. PubMed PMID: 24608443; PubMed Central PMCID: PMC4066331.

3: Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle. 2013 Feb 1;12(3):452-62. doi: 10.4161/cc.23309. Epub 2012 Feb 1. PubMed PMID: 23255218; PubMed Central PMCID: PMC3587446.

4: Zhang G, Liu R, Zhong Y, Plotnikov AN, Zhang W, Zeng L, Rusinova E, Gerona-Nevarro G, Moshkina N, Joshua J, Chuang PY, Ohlmeyer M, He JC, Zhou MM. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51. doi: 10.1074/jbc.M112.359505. Epub 2012 May 29. Erratum in: J Biol Chem. 2012 Nov 9;287(46):38956. PubMed PMID: 22645123; PubMed Central PMCID: PMC3436579.

5: Sayles M, Winter IM. Ambiguous pitch and the temporal representation of inharmonic iterated rippled noise in the ventral cochlear nucleus. J Neurosci. 2008 Nov 12;28(46):11925-38. doi: 10.1523/JNEUROSCI.3137-08.2008. PubMed PMID: 19005058.

6: von Lackum K, Miller JC, Bykowski T, Riley SP, Woodman ME, Brade V, Kraiczy P, Stevenson B, Wallich R. Borrelia burgdorferi regulates expression of complement regulator-acquiring surface protein 1 during the mammal-tick infection cycle. Infect Immun. 2005 Nov;73(11):7398-405. PubMed PMID: 16239539; PubMed Central PMCID: PMC1273877.

MS417

5.0mg / USD 280.0