Quetiapine hemifumarate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318598

CAS#: 111974-72-2 (hemifumarate)

Description: Quetiapine, also known as ICI 204636, is an antipsychotic agent. It targets the serotonin 5-HT2 receptor, histamine H1 receptor, adreneragic alpha1 and alpha2 rectors as well as the dopamine D1 and D2 receptors. It is used in the treatment of schizophrenia, bipolar disorder and depressive disorder.

Price and Availability


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Quetiapine Fumarate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318598
Name: Quetiapine hemifumarate
CAS#: 111974-72-2 (hemifumarate)
Chemical Formula: C46H54N6O8S2
Exact Mass:
Molecular Weight: 883.09
Elemental Analysis: C, 62.56; H, 6.16; N, 9.52; O, 14.49; S, 7.26

Related CAS #: 111974-72-2 (hemifumarate)   111974-69-7 (free base)    

Synonym: ICI 204,636; IC-204,636; ICI204,636; ICI-204636; ICI 204636; ICI204636; Quetiapine Fumarate; Quetiapine hemifumarate; Seroquel XR.

IUPAC/Chemical Name: 2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethan-1-ol; fumarate (2:1)


InChi Code: InChI=1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS#
CAS# 111974-72-2 ( Quetiapine hemifumarate)
CAS#111974-69-7 ( Quetiapine free base).


1: Gonçalves de Lima L, Rossi de Campos D. Development of a level A in vitro-in
vivo correlation for extended release dosage forms of quetiapine fumarate. Drug
Res (Stuttg). 2015 Dec 23. [Epub ahead of print] PubMed PMID: 26697891.

2: Upadhyay P, Trivedi J, Pundarikakshudu K, Sheth N. Comparative study between
simple and optimized liposomal dispersion of quetiapine fumarate for diffusion
through nasal route. Drug Deliv. 2015 Dec 8:1-8. [Epub ahead of print] PubMed
PMID: 26643946.

3: Kalyankar P, Panzade P, Lahoti S. Formulation Design and Optimization of
Orodispersible Tablets of Quetiapine Fumarate by Sublimation Method. Indian J
Pharm Sci. 2015 May-Jun;77(3):267-73. PubMed PMID: 26180271; PubMed Central
PMCID: PMC4502140.

4: Bauer M, Thase ME, Liu S, Earley W, Eriksson H. Analysis of potentially
predictive factors of efficacy of adjunct extended-release quetiapine fumarate in
patients with major depressive disorder. J Psychopharmacol. 2015
May;29(5):565-74. doi: 10.1177/0269881114552715. Epub 2014 Sep 25. PubMed PMID:

5: Kulinowski P, Woyna-Orlewicz K, Rappen GM, Haznar-Garbacz D, Węglarz WP,
Dorożyński PP. An understanding of modified release matrix tablets behavior
during drug dissolution as the key for prediction of pharmaceutical product
performance - case study of multimodal characterization of quetiapine fumarate
tablets. Int J Pharm. 2015 Apr 30;484(1-2):235-45. doi:
10.1016/j.ijpharm.2015.02.040. Epub 2015 Feb 18. PubMed PMID: 25701626.

6: Li JC, Zhang WJ, Zhu JX, Zhu N, Zhang HM, Wang X, Zhang J, Wang QQ.
Preparation and brain delivery of nasal solid lipid nanoparticles of quetiapine
fumarate in situ gel in rat model of schizophrenia. Int J Clin Exp Med. 2015 Oct
15;8(10):17590-600. eCollection 2015. PubMed PMID: 26770349; PubMed Central
PMCID: PMC4694249.

7: Bonafede M, Locklear JC, Wahlqvist P, Fajutrao L, Szamosi J, Pan K, Eriksson
H. Impact of once-daily extended-release quetiapine fumarate on hospitalization
length in patients with acute bipolar mania. J Comp Eff Res. 2015 Jan;4(1):51-9.
doi: 10.2217/cer.14.48. PubMed PMID: 25168473.

8: Kasper S, Montagnani G, Trespi G, Di Fiorino M. Treatment of depressive
symptoms in patients with schizophrenia: a randomized, open-label,
parallel-group, flexible-dose subgroup analysis of patients treated with
extended-release quetiapine fumarate or risperidone. Int Clin Psychopharmacol.
2015 Jan;30(1):14-22. doi: 10.1097/YIC.0000000000000053. PubMed PMID: 25356632.

9: Montgomery SA, Locklear JC, Svedsäter H, Eriksson H. Efficacy of once-daily
extended release quetiapine fumarate in patients with different levels of
severity of generalized anxiety disorder. Int Clin Psychopharmacol. 2014
Sep;29(5):252-62. doi: 10.1097/YIC.0000000000000026. PubMed PMID: 24394383.

10: Locklear JC, Wahlqvist P, Gustafsson U, Udd M, Fajutrao L, Eriksson H. Impact
of extended-release quetiapine fumarate on hospitalization length and cost in
schizophrenia and bipolar disorder patients: a retrospective, hospital-based,
US-cohort analysis. J Comp Eff Res. 2014 Jul;3(4):335-44. doi: 10.2217/cer.14.27.
PubMed PMID: 25275231.

11: Findling RL, Pathak S, Earley WR, Liu S, DelBello MP. Efficacy and safety of
extended-release quetiapine fumarate in youth with bipolar depression: an 8 week,
double-blind, placebo-controlled trial. J Child Adolesc Psychopharmacol. 2014
Aug;24(6):325-35. doi: 10.1089/cap.2013.0105. Epub 2014 Jun 23. PubMed PMID:
24956042; PubMed Central PMCID: PMC4137347.

12: Li Q, Su YA, Liu Y, Chen JX, Tan YL, Yang FD, Si TM. Pharmacokinetics and
tolerability of extended-release quetiapine fumarate in Han Chinese patients with
schizophrenia. Clin Pharmacokinet. 2014 May;53(5):455-65. doi:
10.1007/s40262-013-0127-9. PubMed PMID: 24385309.

13: Weisler R, Montgomery SA, Earley WR, Szamosi J, Eriksson H. Extended release
quetiapine fumarate in patients with major depressive disorder: suicidality data
from acute and maintenance studies. J Clin Psychiatry. 2014 May;75(5):520-7. doi:
10.4088/JCP.13m08624. PubMed PMID: 24816198.

14: Di Fiorino M, Montagnani G, Trespi G, Kasper S. Extended-release quetiapine
fumarate (quetiapine XR) versus risperidone in the treatment of depressive
symptoms in patients with schizoaffective disorder or schizophrenia: a
randomized, open-label, parallel-group, flexible-dose study. Int Clin
Psychopharmacol. 2014 May;29(3):166-76. doi: 10.1097/YIC.0000000000000017. PubMed
PMID: 24681810.

15: Montgomery SA, Altamura AC, Katila H, Datto C, Szamosi J, Eriksson H.
Efficacy of extended release quetiapine fumarate monotherapy in elderly patients
with major depressive disorder: secondary analyses in subgroups of patients
according to baseline anxiety, sleep disturbance, and pain levels. Int Clin
Psychopharmacol. 2014 Mar;29(2):93-105. doi: 10.1097/YIC.0000000000000007. PubMed
PMID: 24162081.

16: Clayton AH, Locklear JC, Svedsäter H, McIntyre RS. Sexual functioning in
patients with major depressive disorder in randomized placebo-controlled studies
of extended release quetiapine fumarate. CNS Spectr. 2014 Apr;19(2):182-96. doi:
10.1017/S1092852913000631. Epub 2013 Sep 25. PubMed PMID: 24067192.

17: McIntyre A, Paisley D, Kouassi E, Gendron A. Quetiapine fumarate
extended-release for the treatment of major depression with comorbid fibromyalgia
syndrome: a double-blind, randomized, placebo-controlled study. Arthritis
Rheumatol. 2014 Feb;66(2):451-61. doi: 10.1002/art.38228. PubMed PMID: 24504819.

18: Wang G, McIntyre A, Earley WR, Raines SR, Eriksson H. A randomized,
double-blind study of the efficacy and tolerability of extended-release
quetiapine fumarate (quetiapine XR) monotherapy in patients with major depressive
disorder. Neuropsychiatr Dis Treat. 2014 Jan 30;10:201-16. doi:
10.2147/NDT.S50248. eCollection 2014. PubMed PMID: 24511235; PubMed Central
PMCID: PMC3916085.

19: Khan A, Atkinson S, Mezhebovsky I, She F, Leathers T, Pathak S.
Extended-release quetiapine fumarate (quetiapine XR) as adjunctive therapy in
patients with generalized anxiety disorder and a history of inadequate treatment
response: a randomized, double-blind study. Ann Clin Psychiatry. 2014
Feb;26(1):3-18. PubMed PMID: 24660224.

20: Bandelow B, Bauer M, Vieta E, El-Khalili N, Gustafsson U, Earley WR, Eriksson
H. Extended release quetiapine fumarate as adjunct to antidepressant therapy in
patients with major depressive disorder: pooled analyses of data in patients with
anxious depression versus low levels of anxiety at baseline. World J Biol
Psychiatry. 2014 Feb;15(2):155-66. doi: 10.3109/15622975.2013.842654. PubMed
PMID: 24506289.