Protriptyline Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318593

CAS#: 1225-55-4 (HCl)

Description: Protriptyline Hydrochloride is a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity.

Chemical Structure

Protriptyline Hydrochloride
CAS# 1225-55-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 318593
Name: Protriptyline Hydrochloride
CAS#: 1225-55-4 (HCl)
Chemical Formula: C19H22ClN
Exact Mass: 0.00
Molecular Weight: 299.840
Elemental Analysis: C, 76.11; H, 7.40; Cl, 11.82; N, 4.67

Price and Availability

Size Price Availability Quantity
10mg USD 250 2 Weeks
50mg USD 550 2 Weeks
500mg USD 950 2 Weeks
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Related CAS #: 438-60-8 (free base)   1225-55-4 (HCl)    

Synonym: Protriptyline Hydrochloride; Concordin; Maximed; Triptyl; Protriptyline HCl; Triptil hydrochloride; Hydrochloride, Protriptyline; Odyssey Brand of Protriptyline Hydrochloride; Protriptyline; Protriptyline Hydrochloride ; Vivactil;

IUPAC/Chemical Name: 3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine;hydrochloride


InChi Code: InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 299.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. doi: 10.3109/10799893.2014.1000464. Epub 2015 Jun 22. PubMed PMID: 26096164.

2: Bansode SB, Jana AK, Batkulwar KB, Warkad SD, Joshi RS, Sengupta N, Kulkarni MJ. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. doi: 10.1371/journal.pone.0105196. eCollection 2014. PubMed PMID: 25141174; PubMed Central PMCID: PMC4139341.

3: Jo SH, Hong HK, Chong SH, Choe H. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life Sci. 2008 Jan 30;82(5-6):331-40. doi: 10.1016/j.lfs.2007.12.004. Epub 2008 Jan 11. PubMed PMID: 18191158.

4: Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest. 1991 Aug;100(2):416-21. PubMed PMID: 1864117.