Propantheline Bromide | CAS#50-34-0 | CAS#298-50-0 | Muscarinic Acetylcholine Receptor Antagonist

Propantheline Bromide
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318584

CAS#: 50-34-0 (Br)

Description: Propantheline bromide inhibits action of acetylcholine at post-ganglionic synapses and acts as a muscarinic acetylcholine receptor antagonist, antispasmodic, and reduces gastric acid secretion. At high doses it has nicotinic effects resulting in neuromuscular blocking. Propantheline bromide competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells.

Chemical Structure

Propantheline Bromide

CAS# 50-34-0 (Br)

Instruction

Theoretical Analysis

MedKoo Cat#: 318584
Name: Propantheline Bromide
CAS#: 50-34-0 (Br)
Chemical Formula: C23H30BrNO3
Exact Mass: 0.00
Molecular Weight: 448.390
Elemental Analysis: C, 61.61; H, 6.74; Br, 17.82; N, 3.12; O, 10.70

Price and Availability

Size	Price	Availability	Quantity
50g	USD -1
1g	USD 80
2g	USD 150
5g	USD 250
10g	USD 450
20g	USD 750
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 50-34-0 (Br) 298-50-0 (free)

Synonym: Propantheline Bromide; Pro-Banthine; Neometantyl; Neopepulsan; Pantheline

IUPAC/Chemical Name: methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium;bromide

InChi Key: XLBIBBZXLMYSFF-UHFFFAOYSA-M

InChi Code: InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1

SMILES Code: CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13)C(C)C.[Br-]

Appearance: White to light yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 448.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gyldenløve M, Thyssen JP. [Propantheline bromide is effective against dog drooling]. Ugeskr Laeger. 2015 Dec 21;177(52). pii: V67934. Danish. PubMed PMID: 26692220.

2: Abd El-Rahman MK, Zaazaa HE, Badr ElDin N, Moustafa AA. Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode. Talanta. 2015 Jan;132:52-8. doi: 10.1016/j.talanta.2014.08.068. Epub 2014 Sep 6. PubMed PMID: 25476278.

3: Baraldi C, Freguglia G, Tinti A, Sparta M, Alexandrova AN, Gamberini MC. IR, Raman and SERS spectra of propantheline bromide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb 15;103:1-10. doi: 10.1016/j.saa.2012.10.070. Epub 2012 Nov 7. PubMed PMID: 23228825.

4: Yu JC, Sung RJ. Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications. Cardiovasc Drugs Ther. 1997 Jan;10(6):687-92. PubMed PMID: 9110111.

5: Jansen T, Plewig G, Hölzle E. [Allergic contact dermatitis due to propantheline bromide]. Dtsch Med Wochenschr. 1996 Jan 5;121(1-2):41-2. German. PubMed PMID: 8565805.

6: Heckerling PS, Ammar KA. Bromide intoxication due to propantheline bromide. Am J Nephrol. 1996;16(6):537-9. PubMed PMID: 8955768.

7: Daniels R, Rupprecht H. Adsorption and chemical stability of a cationic aggregating ester - propantheline bromide - on silica surfaces in aqueous dispersions. Pharm Res. 1985 Jul;2(4):170-5. doi: 10.1023/A:1016336005391. PubMed
PMID: 24272808.

8: Kountourellis JE, Raptouli A. X-ray powder diffraction data for propantheline bromide. Acta Pharm Suec. 1985;22(1):59-61. PubMed PMID: 4024969.

9: Cox SR, Harrington EL, Capponi VJ. Bioavailability studies with ciglitazone in beagles. II. Effect of propantheline bromide and metoclopramide HCL on bioavailability of a tablet. Biopharm Drug Dispos. 1985 Jan-Mar;6(1):81-90. PubMed PMID: 3986303.

10: Ford BL, Wall AK, Johnston MA, Lea AR. Identification of a propantheline analog in propantheline bromide tablets. J Assoc Off Anal Chem. 1984 Sep-Oct;67(5):934-9. PubMed PMID: 6501158.

11: Hongo M, Traube M, McCallum RW. Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers. Dig Dis Sci. 1984 Apr;29(4):300-4. PubMed PMID: 6705640.

12: Charles BG, Ravenscroft PJ, Jacobsen NW. Analysis of propantheline bromide in serum by high-performance liquid chromatography. J Chromatogr. 1984 Mar 9;306:424-8. PubMed PMID: 6715483.

13: Moses DK, Charles BG, Ravenscroft PJ, Whyte IM. Food reduces the oral bioavailability of propantheline bromide in healthy subjects. Br J Clin Pharmacol. 1983 Dec;16(6):758-9. PubMed PMID: 6661368; PubMed Central PMCID: PMC1428342.

14: Rigby GV, Vose CW, Haskins NJ, Allan EF, Harrison IR, Shelton JR, Brownsill RD, Perkins RM, Ford GC, Hawkins AJ, et al. Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine. Eur J Drug Metab Pharmacokinet. 1983 Jul-Sep;8(3):219-24. PubMed PMID: 6689152.

15: Davis BM, Mathé AA, Mohs RC, Levy MI, Davis KL. Effects of propantheline bromide on basal growth hormone, cortisol and prolactin levels. Psychoneuroendocrinology. 1983;8(1):103-7. PubMed PMID: 6683853.

16: Grijalva CV, Novin D, Cooper PH. Facilitation of recovery by propantheline bromide after lateral hypothalamic damage. Brain Res Bull. 1980 Sep-Oct;5(5):525-9. PubMed PMID: 7427753.

17: Duane WC, Bond JH Jr. Prolongation of intestinal transit and expansion of bile acid pools by propantheline bromide. Gastroenterology. 1980 Feb;78(2):226-30. PubMed PMID: 7350044.

18: Dajani EZ, Bianchi RG, Calhoun DW. Synergistic actions of propantheline bromide with cimetidine and thiopropazate hydrochloride in the prevention of stress ulcer formation in rats. J Pharmacol Exp Ther. 1979 Sep;210(3):373-7. PubMed PMID: 573317.

19: Brannon WL, Benson WR, Smith MM. Identification tests for propantheline bromide. J Assoc Off Anal Chem. 1979 Jul;62(4):808-11. PubMed PMID: 500531.

20: Vose CW, Ford GC, Grigson SJ, Haskins NJ, Prout M, Stevens PM, Rose DA, Palmer RF, Rudel H. Pharmacokinetics of propantheline bromide in normal man. Br J Clin Pharmacol. 1979 Jan;7(1):89-93. PubMed PMID: 760746; PubMed Central PMCID: PMC1429618.

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Propantheline Bromide featured