Promethazine Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318582

CAS#: 58-33-3 (HCl)

Description: Promethazine Hydrochloride is an antiemetic, antihistaminic, and CNS depressant. Promethazine Hydrochloride is a first generation histamine H1 receptor antagonist whose antihistamine activity. Promethazine can penetrate the CNS, depressing central H1-receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors.

Chemical Structure

Promethazine Hydrochloride
CAS# 58-33-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 318582
Name: Promethazine Hydrochloride
CAS#: 58-33-3 (HCl)
Chemical Formula: C17H21ClN2S
Exact Mass:
Molecular Weight: 320.88
Elemental Analysis: C, 63.63; H, 6.60; Cl, 11.05; N, 8.73; S, 9.99

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 350.0 2 Weeks
20.0g USD 450.0 2 Weeks
50.0g USD 550.0 2 Weeks
100.0g USD 650.0 2 Weeks
200.0g USD 750.0 2 Weeks
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Related CAS #: 60-87-7 (free base)   58-33-3 (HCl)   96590-75-9 (hibenzate)  

Synonym: Promethazine Hydrochloride; Phenergan; Promethazine Hcl; Fenergan; N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride; Prothazin; Pyrethia; Remsed; Rumergan; Promet; Prometazin; sopromethazine; Phenargan; Phenergan; Phensedyl; Pipolfen; Pipolphen;

IUPAC/Chemical Name: N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride


InChi Code: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 320.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Lalfamkima F, Debnath SC, Adhyapok AK. A study of promethazine hydrochloride
and pentazocine intramuscular sedation along with 2 % lidocaine hydrochloride and
adrenaline and comparison to placebo along with 2 % lidocaine hydrochloride and
adrenaline for surgical extraction of mandibular third molar. J Maxillofac Oral
Surg. 2015 Mar;14(1):90-100. doi: 10.1007/s12663-013-0595-3. Epub 2013 Nov 30.
PubMed PMID: 25729232; PubMed Central PMCID: PMC4339336.

2: Peacock GF, Sauvageot J. Evaluation of the stability of promethazine
hydrochloride in pluronic lecithin organogel and the determination of an
appropriate beyond-use date. Int J Pharm Compd. 2014 Jul-Aug;18(4):345-7. PubMed
PMID: 25508643.

3: Peacock GF, Sauvageot J. Evaluation of the stability of promethazine
hydrochloride in pluronic lecithin organogel and the determination of an
appropriate beyond-use date. Int J Pharm Compd. 2014 Jul-Aug;18(4):345-7. PubMed
PMID: 25474864.

4: G Dehghan MH, Marzuka M. Lyophilized Chitosan/xanthan Polyelectrolyte Complex
Based Mucoadhesive Inserts for Nasal Delivery of Promethazine Hydrochloride. Iran
J Pharm Res. 2014 Summer;13(3):769-84. PubMed PMID: 25276178; PubMed Central
PMCID: PMC4177638.

5: Wyszomirska E, Czerwińska K, Kublin E, Mazurek AP. Identification and
determination of ketotifen hydrogen fumarate, azelastine hydrochloride,
dimetindene maleate and promethazine hydrochloride by densitometric method. Acta
Pol Pharm. 2013 Nov-Dec;70(6):951-9. PubMed PMID: 24383318.

6: Mahajan RK, Mahajan S, Bhadani A, Singh S. Physicochemical studies of
pyridinium gemini surfactants with promethazine hydrochloride in aqueous
solution. Phys Chem Chem Phys. 2012 Jan 14;14(2):887-98. doi: 10.1039/c1cp22448d.
Epub 2011 Nov 25. PubMed PMID: 22119804.

7: He LL, Wang X, Liu B, Wang J, Sun YG, Xu SK. Study on the sonodynamic activity
and mechanism of promethazine hydrochloride by multi-spectroscopic techniques.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):698-705. doi:
10.1016/j.saa.2011.07.006. Epub 2011 Jul 8. PubMed PMID: 21788155.

8: Naqvi AZ, Khatoon S, Kabir-ud-Din. Cloud point variation of amphiphilic drug
promethazine hydrochloride with added surfactants. Colloids Surf B Biointerfaces.
2011 Dec 1;88(2):568-73. doi: 10.1016/j.colsurfb.2011.07.034. Epub 2011 Jul 23.
PubMed PMID: 21871787.

9: Asghar MN, Khan IU, Bano N. In vitro antioxidant and radical-scavenging
capacities of Citrullus colocynthes (L) and Artemisia absinthium extracts using
promethazine hydrochloride radical cation and contemporary assays. Food Sci
Technol Int. 2011 Oct;17(5):481-94. doi: 10.1177/1082013211399495. Epub 2011 Sep
27. PubMed PMID: 21954313.

10: Xi X, Ming L, Liu J. Voltammetric determination of promethazine hydrochloride
at a multi-wall carbon nanotube modified glassy carbon electrode. Drug Test Anal.
2011 Mar;3(3):182-6. doi: 10.1002/dta.205. Epub 2010 Dec 1. PubMed PMID:

11: Kabir-Ud-Din, Rub MA, Naqvi AZ. Mixed micelles of amphiphilic drug
promethazine hydrochloride and surfactants (conventional and gemini) at 293.15K
to 308.15K: Composition, interaction and stability of the aggregates. J Colloid
Interface Sci. 2011 Feb 15;354(2):700-8. doi: 10.1016/j.jcis.2010.11.005. Epub
2010 Nov 11. PubMed PMID: 21134682.

12: Hassan AK, Saad B, Ghani SA, Adnan R, Rahim AA, Ahmad N, Mokhtar M, Ameen ST,
Al-Araji SM. Ionophore-based potentiometric sensors for the flow-injection
determination of promethazine hydrochloride in pharmaceutical formulations and
human urine. Sensors (Basel). 2011;11(1):1028-42. doi: 10.3390/s110101028. Epub
2011 Jan 18. PubMed PMID: 22346617; PubMed Central PMCID: PMC3274102.

13: Chen P, Hu X, Liu S, Liu Z, Song Y. Study on the resonance nonlinear
scattering spectra of the interactions of promethazine hydrochloride and
chlorpromazine hydrochloride with 12-tungstophosphoric acid and their analytical
applications. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 15;77(1):207-12.
doi: 10.1016/j.saa.2010.05.009. Epub 2010 May 24. PubMed PMID: 20541454.

14: Clatts M, Giang le M, Goldsamt L, Colón-López V. Nonmedical use of
promethazine hydrochloride among heroin injectors in Vietnam: unrecognized risks
and unintended consequences. Subst Use Misuse. 2010 Mar;45(4):515-27. doi:
10.3109/10826080903452520. PubMed PMID: 20141462.

15: Liu P, Liang S, Wang BJ, Guo RC. Pharmacokinetics, safety and tolerance of
single- and multiple-dose of a novel compound tramadol hydrochloride injection
(35 mg tramadol hydrochloride, 45 mgl promethazine hydrochloride) in Chinese
healthy subjects. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):193-200.
PubMed PMID: 20166438.

16: Liu P, Liang S, Wang BJ, Guo RC. Development and validation of a sensitive
LC-MS method for the determination of promethazine hydrochloride in human plasma
and urine. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):177-84. PubMed
PMID: 20166436.

17: Thumma S, Repka MA. Compatibility studies of promethazine hydrochloride with
tablet excipients by means of thermal and non-thermal methods. Pharmazie. 2009
Mar;64(3):183-9. PubMed PMID: 19348341.

18: Alam MS, Naqvi AZ, Kabir-ud-Din. Influence of electrolytes/non-electrolytes
on the cloud point phenomenon of the aqueous promethazine hydrochloride drug
solution. J Colloid Interface Sci. 2007 Feb 1;306(1):161-5. Epub 2006 Oct 14.
PubMed PMID: 17069828.

19: Gereli G, Seki Y, Murat Kuşoğlu I, Yurdakoç K. Equilibrium and kinetics for
the sorption of promethazine hydrochloride onto K10 montmorillonite. J Colloid
Interface Sci. 2006 Jul 1;299(1):155-62. Epub 2006 Mar 9. PubMed PMID: 16527295.

20: Kubacák P, Mikus P, Valásková I, Havránek E. Determination of promethazine
hydrochloride in pharmaceuticals by capillary isotachophoresis. Methods Find Exp
Clin Pharmacol. 2005 Oct;27(8):529-32. PubMed PMID: 16273131.