KM11060
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MedKoo CAT#: 522701

CAS#: 774549-97-2

Description: KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 850 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2850 2 Weeks
2g USD 3950 2 Weeks
5g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

KM11060, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522701
Name: KM11060
CAS#: 774549-97-2
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:


Synonym: KM11060; KM-11060; KM 11060.

IUPAC/Chemical Name: 7-chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)quinoline

InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2

SMILES Code: O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wu H, Yang J, Su EM, Li L, Zhao C, Yang X, Gao Z, Pan M, Sun P, Sun W, Jiang
Y, Su X. Lipoxin A4 and platelet activating factor are involved in E. coli or
LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar
26;9(3):e93003. doi: 10.1371/journal.pone.0093003. eCollection 2014. PubMed PMID:
24671173; PubMed Central PMCID: PMC3966846.

2: Loo TW, Bartlett MC, Shi L, Clarke DM. Corrector-mediated rescue of
misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump. Biochem
Pharmacol. 2012 Feb 1;83(3):345-54. doi: 10.1016/j.bcp.2011.11.014. Epub 2011 Nov
28. PubMed PMID: 22138447.

3: Robert R, Carlile GW, Pavel C, Liu N, Anjos SM, Liao J, Luo Y, Zhang D, Thomas
DY, Hanrahan JW. Structural analog of sildenafil identified as a novel corrector
of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.
Epub 2007 Nov 1. PubMed PMID: 17975008.