WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407312

CAS#: 163769-88-8

Description: YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells.

Chemical Structure

CAS# 163769-88-8

Theoretical Analysis

MedKoo Cat#: 407312
Name: YM-90709
CAS#: 163769-88-8
Chemical Formula: C22H21N3O2
Exact Mass: 359.1634
Molecular Weight: 359.429
Elemental Analysis: C, 73.52; H, 5.89; N, 11.69; O, 8.90

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 2 Weeks
25.0mg USD 250.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 650.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 3950.0 2 Weeks
5.0g USD 6550.0 2 Weeks
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Synonym: YM-90709; YM 90709; YM90709.

IUPAC/Chemical Name: 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline


InChi Code: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 359.429 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Morokata T, Suzuki K, Ida K, Yamada T. Effect of a novel interleukin-5
receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into
the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5. Epub 2004 Nov 28.
PubMed PMID: 15790522.

2: Morokata T, Suzuki K, Ida K, Tsuchiyama H, Ishikawa J, Yamada T. Effect of a
novel interleukin-5 receptor antagonist, YM-90709
on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004
Jul;4(7):873-83. PubMed PMID: 15182727.

3: Morokata T, Ida K, Yamada T. Characterization of YM-90709 as a novel
antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.
Int Immunopharmacol. 2002 Nov;2(12):1693-702. PubMed PMID: 12469943.


10.0mg / USD 150.0