BMS-687453
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MedKoo CAT#: 522700

CAS#: 1000998-59-3

Description: BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist. with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. BMS-687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 125 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 3250 2 Weeks
2g USD 5450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-24. Prices are subject to change without notice.

BMS-687453, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522700
Name: BMS-687453
CAS#: 1000998-59-3
Chemical Formula: C22H21ClN2O6
Exact Mass: 444.1088
Molecular Weight: 444.868
Elemental Analysis: C, 59.40; H, 4.76; Cl, 7.97; N, 6.30; O, 21.58


Synonym: BMS-687453; BMS 687453; BMS687453.

IUPAC/Chemical Name: N-(3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)-N-(methoxycarbonyl)glycine

InChi Key: UJIBXDMNCMEJAY-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21ClN2O6/c1-14-19(24-21(31-14)16-6-8-17(23)9-7-16)13-30-18-5-3-4-15(10-18)11-25(12-20(26)27)22(28)29-2/h3-10H,11-13H2,1-2H3,(H,26,27)

SMILES Code: O=C(O)CN(CC1=CC=CC(OCC2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)=C1)C(OC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W,
Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang
H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers
DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M,
Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y,
Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA. Discovery of an
oxybenzylglycine based peroxisome proliferator activated receptor alpha selective
agonist
2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)am
ino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53(7):2854-64. doi:
10.1021/jm9016812. PubMed PMID: 20218621.

2: Vassallo JD, Janovitz EB, Wescott DM, Chadwick C, Lowe-Krentz LJ,
Lehman-McKeeman LD. Biomarkers of drug-induced skeletal muscle injury in the rat:
troponin I and myoglobin. Toxicol Sci. 2009 Oct;111(2):402-12. doi:
10.1093/toxsci/kfp166. Epub 2009 Jul 23. PubMed PMID: 19628585.

3: Mukherjee R, Locke KT, Miao B, Meyers D, Monshizadegan H, Zhang R, Search D,
Grimm D, Flynn M, O'Malley KM, Zhang L, Li J, Shi Y, Kennedy LJ, Blanar M, Cheng
PT, Tino J, Srivastava RA. Novel peroxisome proliferator-activated receptor alpha
agonists lower low-density lipoprotein and triglycerides, raise high-density
lipoprotein, and synergistically increase cholesterol excretion with a liver X
receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26. doi:
10.1124/jpet.108.143271. Epub 2008 Sep 17. PubMed PMID: 18799592.