WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407308
Description: Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours.
MedKoo Cat#: 407308
Chemical Formula: C16H18N2O2S
Exact Mass: 302.1089
Molecular Weight: 302.392
Elemental Analysis: C, 63.55; H, 6.00; N, 9.26; O, 10.58; S, 10.60
IUPAC/Chemical Name: 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
InChi Key: RUOOPLOUUAYNPY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21)
SMILES Code: O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)CC(C)(C)C1