Cytosporone B
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MedKoo CAT#: 523121

CAS#: 321661-62-5

Description: Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 190 Same day
50mg USD 350 Same day
100mg USD 650 Same day
200mg USD 1050 Same day
500mg USD 1950 Same day
1g USD 2950 Same day
2g USD 4950 Same day
5g USD 7650 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-24. Prices are subject to change without notice.

Cytosporone B, purity > 98%, is in stock.The same day shipping out after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 523121
Name: Cytosporone B
CAS#: 321661-62-5
Chemical Formula: C18H26O5
Exact Mass: 322.17802
Molecular Weight: 322.4
Elemental Analysis: C, 67.06; H, 8.13; O, 24.81


Synonym: Cytosporone B; Cytosporone-B; Csn-B; Dothiorelone G; Dothiorelone-G

IUPAC/Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate

InChi Key: UVVWQQKSNZLUQA-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3

SMILES Code: O=C(OCC)CC1=CC(O)=CC(O)=C1C(CCCCCCC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Li J, Lv C, Sun W, Li Z, Han X, Li Y, Shen Y. Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2013 May;57(5):2191-8. doi: 10.1128/AAC.02421-12. Epub 2013 Mar 4. PubMed PMID: 23459474; PubMed Central PMCID: PMC3632957.

2: Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI. Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability. Medchemcomm. 2013 Feb 1;4(2):332-339. PubMed PMID: 24795803; PubMed Central PMCID: PMC4005383.

3: Zhan Y, Du X, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC, Shen Y, Wu Q. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol. 2008 Sep;4(9):548-56. doi: 10.1038/nchembio.106. PubMed PMID: 18690216.