Pitavastatin calcium
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MedKoo CAT#: 318503

CAS#: 147526-32-7 (calcium)

Description: Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187.


Price and Availability

Size Price Shipping out time Quantity
1g USD 90 Same day
5g USD 250 Same day
10g USD 450 Same day
20g USD 750 Same day
50g USD 1550 Same day
100g USD 2450 Same day
200g USD 4250 2 Weeks
1kg USD 11750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

Pitavastatin Calcium, purity > 98%, is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318503
Name: Pitavastatin calcium
CAS#: 147526-32-7 (calcium)
Chemical Formula: C50H46CaF2N2O8
Exact Mass:
Molecular Weight: 880.98
Elemental Analysis: C, 68.17; H, 5.26; Ca, 4.55; F, 4.31; N, 3.18; O, 14.53


Related CAS #: 147526-32-7 (calcium)   147511-69-1 (free acid)   141750-63-2 (lactone)  

Synonym: Pitavastatin Calcium; Livalo; NK-104; Pitavastatin hemicalcium; Nisvastatin; NK 104; NK-104; P 872441; P-872441; pitavastatin;

IUPAC/Chemical Name: calcium (E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

InChi Key: RHGYHLPFVJEAOC-WUVPNHNWSA-L

InChi Code: InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;

SMILES Code: C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Related CAS#
CAS#147526-32-7 (Pitavastatin Calcium )
CAS#147511-69-1 (Pitavastatin free acid)
CAS#141750-63-2 (Pitavastatin lactone)


References

1: Shang D, Deng S, Yao Z, Wang Z, Ni X, Zhang M, Hu J, Lu H, Zhu X, Huang W, Qiu
C, Wen Y. The effect of food on the pharmacokinetic properties and bioequivalence
of two formulations of pitavastatin calcium in healthy Chinese male subjects.
Xenobiotica. 2016 Jan;46(1):34-9. doi: 10.3109/00498254.2015.1046153. Epub 2015
Jul 17. PubMed PMID: 26186644.

2: Luo Z, Zhang Y, Gu J, Feng P, Wang Y. Pharmacokinetic Properties of Single-
and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers.
Curr Ther Res Clin Exp. 2015 Mar 3;77:52-7. doi: 10.1016/j.curtheres.2015.02.001.
eCollection 2015 Dec. PubMed PMID: 26082816; PubMed Central PMCID: PMC4460194.

3: Xiong F, Wang H, Yan L, Xu L, Tao Y, Wu Y, Chen F. Diastereoselective
synthesis of pitavastatin calcium via bismuth-catalyzed two-component
hemiacetal/oxa-Michael addition reaction. Org Biomol Chem. 2015 Oct
14;13(38):9813-9. doi: 10.1039/c5ob01148e. PubMed PMID: 26275074.

4: Zhao J, Yan HM, Li Y, Wang J, Han L, Wang ZH, Tang MX, Zhang W, Zhang Y, Zhong
M. Pitavastatin calcium improves endothelial function and delays the progress of
atherosclerosis in patients with hypercholesterolemia. J Zhejiang Univ Sci B.
2015 May;16(5):380-7. doi: 10.1631/jzus.B1400181. PubMed PMID: 25990055; PubMed
Central PMCID: PMC4432990.

5: Huang YH, Li ZQ, Pan GX, Li YF, Liu Y, Sun JX, Gu XF, Li N, Wang BH.
Comparison of scaled-average, population, and individual bioequivalence on 2
tablets of pitavastatin calcium: a 3-period, reference-replicated, crossover
study in healthy Chinese volunteers. Clin Ther. 2014 Sep 1;36(9):1205-1216.e6.
doi: 10.1016/j.clinthera.2014.06.021. PubMed PMID: 25234550.

6: Panchal HJ, Suhagia BN. Method development and validation of LC and
densitometric-TLC for simultaneous determination of pitavastatin calcium and
ezetimibe in a binary mixture. J AOAC Int. 2014 Jan-Feb;97(1):99-104. PubMed
PMID: 24672865.

7: Yee LL, Wright EA. Pitavastatin calcium: clinical review of a new
antihyperlipidemic medication. Clin Ther. 2011 Aug;33(8):1023-42. doi:
10.1016/j.clinthera.2011.07.011. Epub 2011 Aug 4. Review. PubMed PMID: 21816477.

8: Yan HM, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH, Li L, Zhang Y, Zhang W, Zhong
M. The effect of pitavastatin calcium on endothelial dysfunction induced by
hypercholesterolemia. Expert Opin Pharmacother. 2011 Jul;12(10):1463-71. doi:
10.1517/14656566.2011.583238. PubMed PMID: 21651447.

9: Cheng X, Wang L, Yang G, Cheng J, Zhang Y. [Chiral separation of pitavastatin
calcium enantiomers by capillary zone electrophoresis]. Se Pu. 2010
Nov;28(11):1089-93. Chinese. PubMed PMID: 21381428.

10: Hussar DA, Christian ME. New drugs: pitavastatin calcium, vigabatrin, and
romidepsin. J Am Pharm Assoc (2003). 2010 Jul-Aug;50(4):548-51. doi:
10.1331/JAPhA.2010.10530. PubMed PMID: 20621877.

11: Vadia NH, Patel V, Bhalara HN. Spectrophotometric Determination of Cefetamet
Pivoxil Hydrochloride and Pitavastatin Calcium in Tablet Dosage form. Indian J
Pharm Sci. 2008 Sep;70(5):649-51. doi: 10.4103/0250-474X.45408. PubMed PMID:
21394266; PubMed Central PMCID: PMC3038294.

12: Panchal HJ, Suhagia BN, Patel MM, Patel BH. Estimation of pitavastatin
calcium in tablet dosage forms by column liquid chromatography and ultraviolet
spectrophotometry. J AOAC Int. 2009 Jan-Feb;92(1):158-64. PubMed PMID: 19382574.