Naftifine HCl

Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318299

CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).

Description: Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 150 2 Weeks
200mg USD 250 2 Weeks
500mg USD 350 2 Weeks
1g USD 550 2 Weeks
2g USD 850 2 Weeks
5g USD 1450 2 Weeks
10g USD 2450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-30. Prices are subject to change without notice.

Naftifine HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318299
Name: Naftifine HCl
CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).
Chemical Formula: C21H22ClN
Exact Mass:
Molecular Weight: 323.864
Elemental Analysis: C, 77.88; H, 6.85; Cl, 10.95; N, 4.32

Synonym: AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin

IUPAC/Chemical Name: (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride


InChi Code: InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)/t11-/m1/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Del Rosso JQ, Kircik LH. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. J Drugs Dermatol. 2013 Nov;12(11 Suppl):s165-71. Review. PubMed PMID: 24196340.

2: Gupta AK, Ryder JE, Cooper EA. Naftifine: a review. J Cutan Med Surg. 2008 Mar-Apr;12(2):51-8. Review. PubMed PMID: 18346400.

3: Mühlbacher JM. Naftifine: a topical allylamine antifungal agent. Clin Dermatol. 1991 Oct-Dec;9(4):479-85. Review. PubMed PMID: 1822408.

4: Monk JP, Brogden RN. Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1991 Oct;42(4):659-72. Review. PubMed PMID: 1723367.