Naftifine HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318299

CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).

Description: Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.


Chemical Structure

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Naftifine HCl
CAS# 65473-14-5 (HCl); 65472-88-0 (free base).

Theoretical Analysis

MedKoo Cat#: 318299
Name: Naftifine HCl
CAS#: 65473-14-5 (HCl); 65472-88-0 (free base).
Chemical Formula: C21H22ClN
Exact Mass:
Molecular Weight: 323.864
Elemental Analysis: C, 77.88; H, 6.85; Cl, 10.95; N, 4.32

Price and Availability

Size Price Availability Quantity
100.0mg USD 150.0 2 Weeks
200.0mg USD 250.0 2 Weeks
500.0mg USD 350.0 2 Weeks
1.0g USD 550.0 2 Weeks
2.0g USD 850.0 2 Weeks
5.0g USD 1450.0 2 Weeks
10.0g USD 2450.0 2 Weeks
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Synonym: AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin

IUPAC/Chemical Name: (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochloride

InChi Key: PGYDRGZVXVVZQC-LLVKDONJSA-N

InChi Code: InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)/t11-/m1/s1

SMILES Code: CN(CC1=C2C=CC=CC2=CC=C1)C/C=C/C3=CC=CC=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 323.864 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Del Rosso JQ, Kircik LH. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis. J Drugs Dermatol. 2013 Nov;12(11 Suppl):s165-71. Review. PubMed PMID: 24196340.

2: Gupta AK, Ryder JE, Cooper EA. Naftifine: a review. J Cutan Med Surg. 2008 Mar-Apr;12(2):51-8. Review. PubMed PMID: 18346400.

3: Mühlbacher JM. Naftifine: a topical allylamine antifungal agent. Clin Dermatol. 1991 Oct-Dec;9(4):479-85. Review. PubMed PMID: 1822408.

4: Monk JP, Brogden RN. Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1991 Oct;42(4):659-72. Review. PubMed PMID: 1723367.