Sulfacytine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318762

CAS#: 17784-12-2

Description: Sulfacytine is a short-acting sulfonamide antibiotic, taken orally for treatment against bacterial infections. Sulfonamides, as a group of antibiotics, work by inhibiting the bacterial synthesis of folate.


Chemical Structure

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Sulfacytine
CAS# 17784-12-2

Theoretical Analysis

MedKoo Cat#: 318762
Name: Sulfacytine
CAS#: 17784-12-2
Chemical Formula: C12H14N4O3S
Exact Mass: 294.08
Molecular Weight: 294.329
Elemental Analysis: C, 48.97; H, 4.79; N, 19.04; O, 16.31; S, 10.89

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Synonym: CI636; CI-636; CI 636; Sulfacytine; Renoquid; Sulfacitinum

IUPAC/Chemical Name: 4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzenesulfonamide

InChi Key: SIBQAECNSSQUOD-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N4O3S/c1-2-16-8-7-11(14-12(16)17)15-20(18,19)10-5-3-9(13)4-6-10/h3-8H,2,13H2,1H3,(H,14,15,17)

SMILES Code: O=C1N(CC)C=CC(NS(=O)(C2=CC=C(N)C=C2)=O)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 294.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jensen PA, Mueller JM. Sulfacytine vs. sulfisoxazole for urinary tract infections in an obstetric-gynecologic population. Curr Ther Res Clin Exp. 1976 Jun;19(6):573-8. PubMed PMID: 819216.

2: Sulfacytine. Med Lett Drugs Ther. 1976 May 7;18(10):43-4. PubMed PMID: 1272189.

3: Cohen AE. Sulfacytine in uncomplicated urinary tract infections. Double-blind comparison with sulfisoxazole. Urology. 1976 Mar;7(3):267-71. PubMed PMID: 769287.

4: Way KE. Double-blind comparison of sulfacytine, a new sulfonamide, with sulfisoxazole in acute uncomplicated urinary tract infections. Curr Ther Res Clin Exp. 1976 Feb;19(2):220-9. PubMed PMID: 813961.

5: Hughes J, Roberts LC, Coppridge AJ. Sulfacytine: a new sulfonamide. Double-blind comparison with sulfisoxazole in acute uncomplicated urinary tract infections. J Urol. 1975 Dec;114(6):912-4. PubMed PMID: 1195474.

6: Moyer CE, Goulet JR, Smith TC. A study of the effects of long-term administration of sulfacytine, a new sulfonamide, on the kidney function of man. J Clin Pharmacol New Drugs. 1972 Jul;12(7):254-8. PubMed PMID: 4483531.

7: McCarthy CG. Clinical study new short acting sulfanilamide (sulfacytine). Protocol 636-48. Rocky Mt Med J. 1972 May;69(5):45-8. PubMed PMID: 4556218.

8: Berman HA, Barza M, Weinstein L. Serum sulfonamide concentration after oral administration: comparison of results of chemical assay with two bioassay techniques. Antimicrob Agents Chemother. 1972 Mar;1(3):268-73. PubMed PMID: 5045472; PubMed Central PMCID: PMC444204.

9: Moffat NA, Wenzel FJ. The treatment of urinary tract infections with sulfacytine, a new soluble sulfonamide. Curr Ther Res Clin Exp. 1971 May;13(5):286-91. PubMed PMID: 4998391.

10: Heifetz CL, Chodubski JA, DeCarlo MO, Fisher MW. Disc-agar diffusion microbiological assay procedure for determining serum and urine levels of sulfacytine and other sulfonamides. Appl Microbiol. 1971 May;21(5):893-8. PubMed PMID: 4930038; PubMed Central PMCID: PMC377304.