C-DIM12
new
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522683

CAS#: 178946-89-9

Description: C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 650 2 Weeks
500mg USD 1250 2 Weeks
1g USD 1850 2 Weeks
5g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

C-DIM12 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 522683
Name: C-DIM12
CAS#: 178946-89-9
Chemical Formula: C23H17ClN2
Exact Mass: 356.108
Molecular Weight: 356.853
Elemental Analysis: C, 77.41; H, 4.80; Cl, 9.93; N, 7.85


Synonym: C-DIM12; C-DIM 12; C-DIM-12.

IUPAC/Chemical Name: 1,1-bis(3-indolyl)-1-(p-chlorophenyl)methane

InChi Key: LTLRXTDMXOFBDW-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H

SMILES Code: ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1


Technical Data

Appearance:
Light Brown solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces
dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity
in vitro. Neurosci Lett. 2015 Oct 21;607:83-9. doi: 10.1016/j.neulet.2015.09.015.
Epub 2015 Sep 14. PubMed PMID: 26383113; PubMed Central PMCID: PMC4631643.

2: De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S,
Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane
Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting
Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi:
10.1124/mol.114.095398. Epub 2015 Apr 9. PubMed PMID: 25858541; PubMed Central
PMCID: PMC4429718.

3: De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel
para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and
suppress glial activation in a mouse model of Parkinson's disease. Toxicol Sci.
2015 Feb;143(2):360-73. doi: 10.1093/toxsci/kfu236. Epub 2014 Nov 17. PubMed
PMID: 25406165; PubMed Central PMCID: PMC4306720.

4: De Miranda BR, Miller JA, Hansen RJ, Lunghofer PJ, Safe S, Gustafson DL,
Colagiovanni D, Tjalkens RB. Neuroprotective efficacy and pharmacokinetic
behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in
a mouse model of Parkinson's disease. J Pharmacol Exp Ther. 2013
Apr;345(1):125-38. doi: 10.1124/jpet.112.201558. Epub 2013 Jan 14. PubMed PMID:
23318470.