WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522682

CAS#: 1599432-08-2

Description: NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). NIBR-189 blocks migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2850 2 Weeks
2g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-26. Prices are subject to change without notice.

NIBR-189, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 522682
Name: NIBR-189
CAS#: 1599432-08-2
Chemical Formula: C21H21BrN2O3
Exact Mass: 428.0736
Molecular Weight: 429.314
Elemental Analysis: C, 58.75; H, 4.93; Br, 18.61; N, 6.53; O, 11.18

Synonym: NIBR-189; NIBR 189; NIBR189.

IUPAC/Chemical Name: (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one


InChi Code: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+

SMILES Code: O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA,
Marsilje TH, Seuwen K, Nguyen DG, Sailer AW. Identification and characterization
of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2)
receptor. J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub
2014 Apr 15. PubMed PMID: 24678947.