WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522682
CAS#: 1599432-08-2
Description: NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). NIBR-189 blocks migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.
MedKoo Cat#: 522682
Name: NIBR-189
CAS#: 1599432-08-2
Chemical Formula: C21H21BrN2O3
Exact Mass: 428.0736
Molecular Weight: 429.314
Elemental Analysis: C, 58.75; H, 4.93; Br, 18.61; N, 6.53; O, 11.18
Synonym: NIBR-189; NIBR 189; NIBR189.
IUPAC/Chemical Name: (E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
InChi Key: OFHXXBRBGWUOHR-NYYWCZLTSA-N
InChi Code: InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+
SMILES Code: O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3
1: Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA,
Marsilje TH, Seuwen K, Nguyen DG, Sailer AW. Identification and characterization
of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2)
receptor. J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub
2014 Apr 15. PubMed PMID: 24678947.