LJI308
new
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407301

CAS#: 1627709-94-7

Description: LJI308 is a RSK inhibitor. LJI308 overcomes chemoresistance by eliminating cancer stem cells. LJI308 targets the CSC population and repress TNBC growth and dissemination. LJI308 specifically targeted transformed cells as it had little effect on the non-tumorigenic parental HMECs. Targeting RSK using specific and potent inhibitors, such as LJI308, delivers the promise of inhibiting the growth of TNBC.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 120 2 Weeks
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 4150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

LJI308, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 407301
Name: LJI308
CAS#: 1627709-94-7
Chemical Formula: C21H18F2N2O2
Exact Mass: 368.1336
Molecular Weight: 368.3838
Elemental Analysis: C, 68.47; H, 4.93; F, 10.31; N, 7.60; O, 8.69


Synonym: LJI308; LJI-308; LJI 308; NVP-LJI308; NVP-LJI-308; NVP-LJI 308.

IUPAC/Chemical Name: 2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-phenol

InChi Key: YUYJEQHNWKQNBT-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2

SMILES Code: OC1=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Davies AH, Reipas K, Hu K, Berns R, Firmino N, Stratford AL, Dunn SE.
Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes
chemoresistance by eliminating cancer stem cells. Oncotarget. 2015 Aug
21;6(24):20570-7. PubMed PMID: 26011941; PubMed Central PMCID: PMC4653026.

2: Aronchik I, Appleton BA, Basham SE, Crawford K, Del Rosario M, Doyle LV,
Estacio WF, Lan J, Lindvall MK, Luu CA, Ornelas E, Venetsanakos E, Shafer CM,
Jefferson AB. Novel potent and selective inhibitors of p90 ribosomal S6 kinase
reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res.
2014 May;12(5):803-12. doi: 10.1158/1541-7786.MCR-13-0595. Epub 2014 Feb 19.
PubMed PMID: 24554780.