WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522681
Description: PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.
MedKoo Cat#: 522681
Chemical Formula: C15H9NO2
Exact Mass: 235.0633
Molecular Weight: 235.242
Elemental Analysis: C, 76.59; H, 3.86; N, 5.95; O, 13.60
Synonym: PRT4165; PRT-4165; PRT 4165.
IUPAC/Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
SMILES Code: O=C1/C(C(C2=C1C=CC=C2)=O)=C\C3=CC=CN=C3
1: Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ. A small molecule
inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA
double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. doi:
10.1074/jbc.M113.461699. Epub 2013 Jul 30. PubMed PMID: 23902761; PubMed Central