PRT4165
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MedKoo CAT#: 522681

CAS#: 31083-55-3

Description: PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 150 Same day
50mg USD 250 Same day
100mg USD 450 Same day
500mg USD 1350 Same day
1g USD 2450 Same day
2g USD 3450 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

PRT4165, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522681
Name: PRT4165
CAS#: 31083-55-3
Chemical Formula: C15H9NO2
Exact Mass: 235.0633
Molecular Weight: 235.242
Elemental Analysis: C, 76.59; H, 3.86; N, 5.95; O, 13.60


Synonym: PRT4165; PRT-4165; PRT 4165.

IUPAC/Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione

InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H

SMILES Code: O=C1/C(C(C2=C1C=CC=C2)=O)=C\C3=CC=CN=C3


Technical Data

Appearance:
Yellow solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ. A small molecule
inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA
double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. doi:
10.1074/jbc.M113.461699. Epub 2013 Jul 30. PubMed PMID: 23902761; PubMed Central
PMCID: PMC3772243.