WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522681

CAS#: 31083-55-3

Description: PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.

Chemical Structure

CAS# 31083-55-3

Theoretical Analysis

MedKoo Cat#: 522681
Name: PRT4165
CAS#: 31083-55-3
Chemical Formula: C15H9NO2
Exact Mass: 235.06
Molecular Weight: 235.240
Elemental Analysis: C, 76.59; H, 3.86; N, 5.95; O, 13.60

Price and Availability

Size Price Availability Quantity
25mg USD 150 Ready to ship
50mg USD 250 Ready to ship
100mg USD 450 Ready to ship
500mg USD 1350 Ready to ship
1g USD 2450 Ready to ship
2g USD 3450 Ready to ship
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Synonym: PRT4165; PRT-4165; PRT 4165.

IUPAC/Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione


InChi Code: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H

SMILES Code: O=C1/C(C(C2=C1C=CC=C2)=O)=C\C3=CC=CN=C3

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.0 85.00

Preparing Stock Solutions

The following data is based on the product molecular weight 235.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ. A small molecule
inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA
double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. doi:
10.1074/jbc.M113.461699. Epub 2013 Jul 30. PubMed PMID: 23902761; PubMed Central
PMCID: PMC3772243.