WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522681
CAS#: 31083-55-3
Description: PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.
MedKoo Cat#: 522681
Name: PRT4165
CAS#: 31083-55-3
Chemical Formula: C15H9NO2
Exact Mass: 235.0633
Molecular Weight: 235.24
Elemental Analysis: C, 76.59; H, 3.86; N, 5.95; O, 13.60
Synonym: PRT4165; PRT-4165; PRT 4165.
IUPAC/Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
SMILES Code: O=C1/C(C(C2=C1C=CC=C2)=O)=C\C3=CC=CN=C3
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.0 | 85.0 |
The following data is based on the product molecular weight 235.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ismail IH, McDonald D, Strickfaden H, Xu Z, Hendzel MJ. A small molecule
inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA
double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. doi:
10.1074/jbc.M113.461699. Epub 2013 Jul 30. PubMed PMID: 23902761; PubMed Central
PMCID: PMC3772243.
