JNJ-42041935
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MedKoo CAT#: 522678

CAS#: 1193383-09-3

Description: JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can be used to investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia. The hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes represent novel targets for the treatment of anemia, ulcerative colitis, and ischemic and metabolic disease inter alia.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 950 Same day
500mg USD 1950 Same day
1g USD 3250 Same day
2g USD 5950 Same day
Inquire bulk and customized quantity

Pricing updated 2021-01-26. Prices are subject to change without notice.

JNJ-42041935, purity 98% is in stock. The same day shipping after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522678
Name: JNJ-42041935
CAS#: 1193383-09-3
Chemical Formula: C12H6ClF3N4O3
Exact Mass: 346.0081
Molecular Weight: 346.6502
Elemental Analysis: C, 41.58; H, 1.74; Cl, 10.23; F, 16.44; N, 16.16; O, 13.85


Synonym: JNJ-42041935; JNJ 42041935; JNJ42041935.

IUPAC/Chemical Name: 1-(5-chloro-6-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid

InChi Key: FXHHASJVTYRJHH-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H6ClF3N4O3/c13-6-1-7-8(2-9(6)23-12(14,15)16)19-11(18-7)20-4-5(3-17-20)10(21)22/h1-4H,(H,18,19)(H,21,22)

SMILES Code: ClC1=CC2=C(NC(N3C=C(C(O)=O)C=N3)=N2)C=C1OC(F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Binó L, Kučera J, Štefková K, Švihálková Šindlerová L, Lánová M, Kudová J,
Kubala L, Pacherník J. The stabilization of hypoxia inducible factor modulates
differentiation status and inhibits the proliferation of mouse embryonic stem
cells. Chem Biol Interact. 2016 Jan 25;244:204-14. doi:
10.1016/j.cbi.2015.12.007. Epub 2015 Dec 23. PubMed PMID: 26723917.

2: Corcoran A, Kunze R, Harney SC, Breier G, Marti HH, O'Connor JJ. A role for
prolyl hydroxylase domain proteins in hippocampal synaptic plasticity.
Hippocampus. 2013 Oct;23(10):861-72. doi: 10.1002/hipo.22142. Epub 2013 Jun 6.
PubMed PMID: 23674383.

3: Barrett TD, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W,
Young A, Hua H, Hart JC, Tran DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K,
Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH, Shankley NP.
Pharmacological characterization of
1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic
acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl
hydroxylase inhibitor. Mol Pharmacol. 2011 Jun;79(6):910-20. doi:
10.1124/mol.110.070508. Epub 2011 Mar 3. PubMed PMID: 21372172.

4: Kirkham K. American Chemical Society-239th national meeting--Investigating new
therapeutic candidates: part 2. 21-25 March 2010, San Francisco, CA, USA. IDrugs.
2010 May;13(5):292-4. PubMed PMID: 20432181.