Isosorbide Mononitrate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319939

CAS#: 16051-77-7

Description: Isosorbide Mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Research on isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive.


Price and Availability

Size Price Shipping out time Quantity
500mg USD 90 2 Weeks
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 350 2 Weeks
10g USD 550 2 Weeks
20g USD 750 2 Weeks
50g USD 950 2 Weeks
100g USD 1250 2 Weeks
200g USD 1850 2 Weeks
500g USD 2650 2 Weeks
1kg USD 3650 2 Weeks
2kg USD 5650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

Isosorbide Mononitrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319939
Name: Isosorbide Mononitrate
CAS#: 16051-77-7
Chemical Formula: C6H9NO6
Exact Mass: 191.043
Molecular Weight: 191.139
Elemental Analysis: C, 37.70; H, 4.75; N, 7.33; O, 50.22


Synonym: AHR 4698; AHR-4698; BM 22-145; BM 22.145; BRN 5851319; CCRIS 1911; Isosorbide Mononitrate. trade name Monoket, Imdur, Monosorb, Chemydur.

IUPAC/Chemical Name: (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate

InChi Key: YWXYYJSYQOXTPL-SLPGGIOYSA-N

InChi Code: InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

SMILES Code: [O-][N+](O[C@H]1[C@@]2([H])OC[C@@H]([C@]2(OC1)[H])O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Gluud LL, Langholz E, Krag A. Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices. Aliment Pharmacol Ther. 2010 Oct;32(7):859-71. Review. PubMed PMID: 20839387.

2: Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. Angiology. 2000 Aug;51(8):631-8. Review. PubMed PMID: 10959515.

3: Waller DG. Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate. J Cardiovasc Pharmacol. 1999 Aug;34 Suppl 2:S21-7; discussion S29-31. Review. PubMed PMID: 10499557.

4: Prakash A, Markham A. Long-acting isosorbide mononitrate. Drugs. 1999 Jan;57(1):93-9; discussion 100. Review. Erratum in: Drugs 1999 Mar;57(3):438. PubMed PMID: 9951954.

5: Lewin HC, Berman DS. Achieving sustained improvement in myocardial perfusion: role of isosorbide mononitrate. Am J Cardiol. 1997 Jun 26;79(12B):31-5. Review. PubMed PMID: 9223355.

6: Thadani U, de Vane PJ. Efficacy of isosorbide mononitrate in angina pectoris. Am J Cardiol. 1992 Nov 27;70(17):67G-71G. Review. PubMed PMID: 1449103.

7: Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. Review. PubMed PMID: 1449102.