Isosorbide Mononitrate
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MedKoo CAT#: 319939

CAS#: 16051-77-7

Description: Isosorbide Mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Research on isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive.


Chemical Structure

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Isosorbide Mononitrate
CAS# 16051-77-7

Theoretical Analysis

MedKoo Cat#: 319939
Name: Isosorbide Mononitrate
CAS#: 16051-77-7
Chemical Formula: C6H9NO6
Exact Mass: 191.04
Molecular Weight: 191.139
Elemental Analysis: C, 37.70; H, 4.75; N, 7.33; O, 50.22

Price and Availability

Size Price Availability Quantity
500mg USD 150 2 Weeks
1g USD 250 2 Weeks
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Synonym: AHR 4698; AHR-4698; BM 22-145; BM 22.145; BRN 5851319; CCRIS 1911; Isosorbide Mononitrate. trade name Monoket, Imdur, Monosorb, Chemydur.

IUPAC/Chemical Name: (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate

InChi Key: YWXYYJSYQOXTPL-SLPGGIOYSA-N

InChi Code: InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

SMILES Code: [O-][N+](O[C@H]1[C@@]2([H])OC[C@@H]([C@]2(OC1)[H])O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 191.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gluud LL, Langholz E, Krag A. Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices. Aliment Pharmacol Ther. 2010 Oct;32(7):859-71. Review. PubMed PMID: 20839387.

2: Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. Angiology. 2000 Aug;51(8):631-8. Review. PubMed PMID: 10959515.

3: Waller DG. Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate. J Cardiovasc Pharmacol. 1999 Aug;34 Suppl 2:S21-7; discussion S29-31. Review. PubMed PMID: 10499557.

4: Prakash A, Markham A. Long-acting isosorbide mononitrate. Drugs. 1999 Jan;57(1):93-9; discussion 100. Review. Erratum in: Drugs 1999 Mar;57(3):438. PubMed PMID: 9951954.

5: Lewin HC, Berman DS. Achieving sustained improvement in myocardial perfusion: role of isosorbide mononitrate. Am J Cardiol. 1997 Jun 26;79(12B):31-5. Review. PubMed PMID: 9223355.

6: Thadani U, de Vane PJ. Efficacy of isosorbide mononitrate in angina pectoris. Am J Cardiol. 1992 Nov 27;70(17):67G-71G. Review. PubMed PMID: 1449103.

7: Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. Review. PubMed PMID: 1449102.